Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia

Kurzanzeige
dc.contributor.authorSzamosvari, David
dc.contributor.authorProthiwa, Michaela
dc.contributor.authorDieterich, Cora Lisbeth
dc.contributor.authorBöttcher, Thomas
dc.date.accessioned2020-06-16T12:17:43Z
dc.date.available2020-06-16T12:17:43Z
dc.date.issued2020-06-11eng
dc.description.abstractWe synthesized all major saturated and unsaturated 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia, quantified their native production levels and characterized their antibiotic activities against competing Staphylococcus aureus. We demonstrate that quinolone core methylation and position of unsaturation in the alkyl-chain dictate antibiotic potency which supports the proposed mechanism of action.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1039/d0cc02498heng
dc.identifier.pmid32436549eng
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/49886
dc.language.isoengeng
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dc.subject.ddc540eng
dc.titleProfiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderiaeng
dc.typeJOURNAL_ARTICLEeng
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  year={2020},
  doi={10.1039/d0cc02498h},
  title={Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia},
  number={47},
  volume={56},
  issn={0009-241X},
  journal={Chemical Communications : ChemComm},
  pages={6328--6331},
  author={Szamosvari, David and Prothiwa, Michaela and Dieterich, Cora Lisbeth and Böttcher, Thomas}
}
kops.citation.iso690SZAMOSVARI, David, Michaela PROTHIWA, Cora Lisbeth DIETERICH, Thomas BÖTTCHER, 2020. Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia. In: Chemical Communications : ChemComm. Royal Society of Chemistry (RSC). 2020, 56(47), pp. 6328-6331. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/d0cc02498hdeu
kops.citation.iso690SZAMOSVARI, David, Michaela PROTHIWA, Cora Lisbeth DIETERICH, Thomas BÖTTCHER, 2020. Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia. In: Chemical Communications : ChemComm. Royal Society of Chemistry (RSC). 2020, 56(47), pp. 6328-6331. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/d0cc02498heng
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kops.sourcefieldChemical Communications : ChemComm. Royal Society of Chemistry (RSC). 2020, <b>56</b>(47), pp. 6328-6331. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/d0cc02498hdeu
kops.sourcefield.plainChemical Communications : ChemComm. Royal Society of Chemistry (RSC). 2020, 56(47), pp. 6328-6331. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/d0cc02498hdeu
kops.sourcefield.plainChemical Communications : ChemComm. Royal Society of Chemistry (RSC). 2020, 56(47), pp. 6328-6331. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/d0cc02498heng
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