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Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia

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2020

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Dieterich, Cora Lisbeth

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https://doi.org/10.1039/d0cc02498h
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Chemical Communications : ChemComm. Royal Society of Chemistry (RSC). 2020, 56(47), pp. 6328-6331. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/d0cc02498h

Zusammenfassung

We synthesized all major saturated and unsaturated 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia, quantified their native production levels and characterized their antibiotic activities against competing Staphylococcus aureus. We demonstrate that quinolone core methylation and position of unsaturation in the alkyl-chain dictate antibiotic potency which supports the proposed mechanism of action.

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540 Chemie

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ISO 690SZAMOSVARI, David, Michaela PROTHIWA, Cora Lisbeth DIETERICH, Thomas BÖTTCHER, 2020. Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia. In: Chemical Communications : ChemComm. Royal Society of Chemistry (RSC). 2020, 56(47), pp. 6328-6331. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/d0cc02498h
BibTex
@article{Szamosvari2020-06-11Profi-49886,
  year={2020},
  doi={10.1039/d0cc02498h},
  title={Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia},
  number={47},
  volume={56},
  issn={0009-241X},
  journal={Chemical Communications : ChemComm},
  pages={6328--6331},
  author={Szamosvari, David and Prothiwa, Michaela and Dieterich, Cora Lisbeth and Böttcher, Thomas}
}
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