HR22C16 : a potent small-molecule probe for the dynamics of cell division

Kurzanzeige
dc.contributor.authorHotha, Srinivasdeu
dc.contributor.authorYarrow, Justin C.deu
dc.contributor.authorYang, Janet G.deu
dc.contributor.authorGarrett, Sarahdeu
dc.contributor.authorRenduchintala, Kishore V.deu
dc.contributor.authorMayer, Thomas U.
dc.contributor.authorKapoor, Tarun M.deu
dc.date.accessioned2012-01-11T10:40:18Zdeu
dc.date.available2012-01-11T10:40:18Zdeu
dc.date.issued2003-05-30
dc.description.abstractA high-throughput, microscopy-based chemical-genetic screen identified HR22C16, which causes a monoastral mitotic block, as a small-molecule probe for cell division (see picture). By using a diastereoselective, traceless solid-phase synthesis and biological assays, a more potent HR22C16 analogue was then identified. A photocaging strategy for HR22C16 was also developed to allow fast temporal control over the function of the target protein Eg5.eng
dc.description.versionpublished
dc.identifier.citationErsch. in: Angewandte Chemie / Internaional Edition ; 42 (2003), 21. - S. 2379-2382.deu
dc.identifier.doi10.1002/anie.200351173deu
dc.identifier.pmid12783501
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/14051
dc.language.isoengdeu
dc.legacy.dateIssued2012-01-11deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectsmall moleculedeu
dc.subjectEg5deu
dc.subjectKinesindeu
dc.subjectChemical Biologydeu
dc.subjectantimitoticsdeu
dc.subjectinhibitorsdeu
dc.subjectmolecular motorsdeu
dc.subjectphotolysisdeu
dc.subjectsolid-phase synthesisdeu
dc.subjectMitosedeu
dc.subjectchromosomenbandedeu
dc.subjectZellteilungdeu
dc.subjectMikrotubulideu
dc.subjectKinesindeu
dc.subject.ddc570deu
dc.titleHR22C16 : a potent small-molecule probe for the dynamics of cell divisioneng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Hotha2003-05-30HR22C-14051,
  year={2003},
  doi={10.1002/anie.200351173},
  title={HR22C16 : a potent small-molecule probe for the dynamics of cell division},
  number={21},
  volume={42},
  issn={1433-7851},
  journal={Angewandte Chemie International Edition},
  pages={2379--2382},
  author={Hotha, Srinivas and Yarrow, Justin C. and Yang, Janet G. and Garrett, Sarah and Renduchintala, Kishore V. and Mayer, Thomas U. and Kapoor, Tarun M.}
}
kops.citation.iso690HOTHA, Srinivas, Justin C. YARROW, Janet G. YANG, Sarah GARRETT, Kishore V. RENDUCHINTALA, Thomas U. MAYER, Tarun M. KAPOOR, 2003. HR22C16 : a potent small-molecule probe for the dynamics of cell division. In: Angewandte Chemie International Edition. 2003, 42(21), pp. 2379-2382. ISSN 1433-7851. Available under: doi: 10.1002/anie.200351173deu
kops.citation.iso690HOTHA, Srinivas, Justin C. YARROW, Janet G. YANG, Sarah GARRETT, Kishore V. RENDUCHINTALA, Thomas U. MAYER, Tarun M. KAPOOR, 2003. HR22C16 : a potent small-molecule probe for the dynamics of cell division. In: Angewandte Chemie International Edition. 2003, 42(21), pp. 2379-2382. ISSN 1433-7851. Available under: doi: 10.1002/anie.200351173eng
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