Publikation: HR22C16 : a potent small-molecule probe for the dynamics of cell division
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Datum
2003
Autor:innen
Hotha, Srinivas
Yarrow, Justin C.
Yang, Janet G.
Garrett, Sarah
Renduchintala, Kishore V.
Kapoor, Tarun M.
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Erschienen in
Angewandte Chemie International Edition. 2003, 42(21), pp. 2379-2382. ISSN 1433-7851. Available under: doi: 10.1002/anie.200351173
Zusammenfassung
A high-throughput, microscopy-based chemical-genetic screen identified HR22C16, which causes a monoastral mitotic block, as a small-molecule probe for cell division (see picture). By using a diastereoselective, traceless solid-phase synthesis and biological assays, a more potent HR22C16 analogue was then identified. A photocaging strategy for HR22C16 was also developed to allow fast temporal control over the function of the target protein Eg5.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
small molecule, Eg5, Kinesin, Chemical Biology, antimitotics, inhibitors, molecular motors, photolysis, solid-phase synthesis, Mitose, chromosomenbande, Zellteilung, Mikrotubuli, Kinesin
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HOTHA, Srinivas, Justin C. YARROW, Janet G. YANG, Sarah GARRETT, Kishore V. RENDUCHINTALA, Thomas U. MAYER, Tarun M. KAPOOR, 2003. HR22C16 : a potent small-molecule probe for the dynamics of cell division. In: Angewandte Chemie International Edition. 2003, 42(21), pp. 2379-2382. ISSN 1433-7851. Available under: doi: 10.1002/anie.200351173BibTex
@article{Hotha2003-05-30HR22C-14051, year={2003}, doi={10.1002/anie.200351173}, title={HR22C16 : a potent small-molecule probe for the dynamics of cell division}, number={21}, volume={42}, issn={1433-7851}, journal={Angewandte Chemie International Edition}, pages={2379--2382}, author={Hotha, Srinivas and Yarrow, Justin C. and Yang, Janet G. and Garrett, Sarah and Renduchintala, Kishore V. and Mayer, Thomas U. and Kapoor, Tarun M.} }
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