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HR22C16 : a potent small-molecule probe for the dynamics of cell division

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2003

Autor:innen

Hotha, Srinivas
Yarrow, Justin C.
Yang, Janet G.
Garrett, Sarah
Renduchintala, Kishore V.
Kapoor, Tarun M.

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Core Facility der Universität Konstanz

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Published

Erschienen in

Angewandte Chemie International Edition. 2003, 42(21), pp. 2379-2382. ISSN 1433-7851. Available under: doi: 10.1002/anie.200351173

Zusammenfassung

A high-throughput, microscopy-based chemical-genetic screen identified HR22C16, which causes a monoastral mitotic block, as a small-molecule probe for cell division (see picture). By using a diastereoselective, traceless solid-phase synthesis and biological assays, a more potent HR22C16 analogue was then identified. A photocaging strategy for HR22C16 was also developed to allow fast temporal control over the function of the target protein Eg5.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

small molecule, Eg5, Kinesin, Chemical Biology, antimitotics, inhibitors, molecular motors, photolysis, solid-phase synthesis, Mitose, chromosomenbande, Zellteilung, Mikrotubuli, Kinesin

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ISO 690HOTHA, Srinivas, Justin C. YARROW, Janet G. YANG, Sarah GARRETT, Kishore V. RENDUCHINTALA, Thomas U. MAYER, Tarun M. KAPOOR, 2003. HR22C16 : a potent small-molecule probe for the dynamics of cell division. In: Angewandte Chemie International Edition. 2003, 42(21), pp. 2379-2382. ISSN 1433-7851. Available under: doi: 10.1002/anie.200351173
BibTex
@article{Hotha2003-05-30HR22C-14051,
  year={2003},
  doi={10.1002/anie.200351173},
  title={HR22C16 : a potent small-molecule probe for the dynamics of cell division},
  number={21},
  volume={42},
  issn={1433-7851},
  journal={Angewandte Chemie International Edition},
  pages={2379--2382},
  author={Hotha, Srinivas and Yarrow, Justin C. and Yang, Janet G. and Garrett, Sarah and Renduchintala, Kishore V. and Mayer, Thomas U. and Kapoor, Tarun M.}
}
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