Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption : Observing Ubiquitin Activation in Real Time

Kurzanzeige
dc.contributor.authorHacker, Stephan M.
dc.contributor.authorPagliarini, Dana
dc.contributor.authorTischer, Thomas
dc.contributor.authorHardt, Normann
dc.contributor.authorSchneider, Daniel
dc.contributor.authorMex, Martin
dc.contributor.authorMayer, Thomas U.
dc.contributor.authorScheffner, Martin
dc.contributor.authorMarx, Andreas
dc.date.accessioned2013-11-15T19:52:46Zdeu
dc.date.available2013-11-15T19:52:46Zdeu
dc.date.issued2013-11-04
dc.description.abstractMany enzymes use ATP in signal-transducing processes or as an energy source. New fluorogenic ATP analogues signal ATP consumption by ubiquitin-like protein-activating enzymes in real time. Thus the inhibition and stimulation of these ATP-processing enzymes can be studied without auxiliary enzymes and reagents. beta-Lapachone was identified as an inhibitor of the ubiquitin-activating enzyme UBA1 (see scheme; A=acceptor, D=donor).eng
dc.description.versionpublished
dc.identifier.citationAngewandte Chemie International Edition ; 52 (2013), 45. - S. 11916–11919deu
dc.identifier.doi10.1002/anie.201304723deu
dc.identifier.pmid24105922
dc.identifier.ppn46914761X
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/25116
dc.language.isoengdeu
dc.legacy.dateIssued2013-11-15deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subjectATPasesdeu
dc.subjectFRETdeu
dc.subjectlapachonedeu
dc.subjectnucleotidesdeu
dc.subjectubiquitindeu
dc.subject.ddc540deu
dc.titleFluorogenic ATP Analogues for Online Monitoring of ATP Consumption : Observing Ubiquitin Activation in Real Timeeng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Hacker2013-11-04Fluor-25116,
  year={2013},
  doi={10.1002/anie.201304723},
  title={Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption : Observing Ubiquitin Activation in Real Time},
  number={45},
  volume={52},
  issn={1433-7851},
  journal={Angewandte Chemie International Edition},
  pages={11916--11919},
  author={Hacker, Stephan M. and Pagliarini, Dana and Tischer, Thomas and Hardt, Normann and Schneider, Daniel and Mex, Martin and Mayer, Thomas U. and Scheffner, Martin and Marx, Andreas}
}
kops.citation.iso690HACKER, Stephan M., Dana PAGLIARINI, Thomas TISCHER, Normann HARDT, Daniel SCHNEIDER, Martin MEX, Thomas U. MAYER, Martin SCHEFFNER, Andreas MARX, 2013. Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption : Observing Ubiquitin Activation in Real Time. In: Angewandte Chemie International Edition. 2013, 52(45), pp. 11916-11919. ISSN 1433-7851. eISSN 1521-3773. Available under: doi: 10.1002/anie.201304723deu
kops.citation.iso690HACKER, Stephan M., Dana PAGLIARINI, Thomas TISCHER, Normann HARDT, Daniel SCHNEIDER, Martin MEX, Thomas U. MAYER, Martin SCHEFFNER, Andreas MARX, 2013. Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption : Observing Ubiquitin Activation in Real Time. In: Angewandte Chemie International Edition. 2013, 52(45), pp. 11916-11919. ISSN 1433-7851. eISSN 1521-3773. Available under: doi: 10.1002/anie.201304723eng
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kops.submitter.emailkarin.reichardt@uni-konstanz.dedeu
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