Publikation: Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption : Observing Ubiquitin Activation in Real Time
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2013
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Angewandte Chemie International Edition. 2013, 52(45), pp. 11916-11919. ISSN 1433-7851. eISSN 1521-3773. Available under: doi: 10.1002/anie.201304723
Zusammenfassung
Many enzymes use ATP in signal-transducing processes or as an energy source. New fluorogenic ATP analogues signal ATP consumption by ubiquitin-like protein-activating enzymes in real time. Thus the inhibition and stimulation of these ATP-processing enzymes can be studied without auxiliary enzymes and reagents. beta-Lapachone was identified as an inhibitor of the ubiquitin-activating enzyme UBA1 (see scheme; A=acceptor, D=donor).
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
ATPases, FRET, lapachone, nucleotides, ubiquitin
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HACKER, Stephan M., Dana PAGLIARINI, Thomas TISCHER, Normann HARDT, Daniel SCHNEIDER, Martin MEX, Thomas U. MAYER, Martin SCHEFFNER, Andreas MARX, 2013. Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption : Observing Ubiquitin Activation in Real Time. In: Angewandte Chemie International Edition. 2013, 52(45), pp. 11916-11919. ISSN 1433-7851. eISSN 1521-3773. Available under: doi: 10.1002/anie.201304723BibTex
@article{Hacker2013-11-04Fluor-25116,
year={2013},
doi={10.1002/anie.201304723},
title={Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption : Observing Ubiquitin Activation in Real Time},
number={45},
volume={52},
issn={1433-7851},
journal={Angewandte Chemie International Edition},
pages={11916--11919},
author={Hacker, Stephan M. and Pagliarini, Dana and Tischer, Thomas and Hardt, Normann and Schneider, Daniel and Mex, Martin and Mayer, Thomas U. and Scheffner, Martin and Marx, Andreas}
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