Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance

Kurzanzeige
dc.contributor.authorDuffy, David J.
dc.contributor.authorKrstic, Aleksandar
dc.contributor.authorHalasz, Melinda
dc.contributor.authorSchwarzl, Thomas
dc.contributor.authorKonietzny, Anja
dc.contributor.authorIljin, Kristiina
dc.contributor.authorHiggins, Desmond G.
dc.contributor.authorKolch, Walter
dc.date.accessioned2017-04-27T07:51:06Z
dc.date.available2017-04-27T07:51:06Z
dc.date.issued2017eng
dc.description.abstractRetinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of cellular MYCN antagonises these signalling events to prevent differentiation and confer resistance.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1186/s13073-017-0407-3eng
dc.identifier.pmid28187790eng
dc.identifier.ppn487006895
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/38631
dc.language.isoengeng
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.ddc570eng
dc.titleRetinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistanceeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Duffy2017Retin-38631,
  year={2017},
  doi={10.1186/s13073-017-0407-3},
  title={Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance},
  number={1},
  volume={9},
  journal={Genome Medicine},
  author={Duffy, David J. and Krstic, Aleksandar and Halasz, Melinda and Schwarzl, Thomas and Konietzny, Anja and Iljin, Kristiina and Higgins, Desmond G. and Kolch, Walter},
  note={Article Number: 15}
}
kops.citation.iso690DUFFY, David J., Aleksandar KRSTIC, Melinda HALASZ, Thomas SCHWARZL, Anja KONIETZNY, Kristiina ILJIN, Desmond G. HIGGINS, Walter KOLCH, 2017. Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance. In: Genome Medicine. 2017, 9(1), 15. eISSN 1756-994X. Available under: doi: 10.1186/s13073-017-0407-3deu
kops.citation.iso690DUFFY, David J., Aleksandar KRSTIC, Melinda HALASZ, Thomas SCHWARZL, Anja KONIETZNY, Kristiina ILJIN, Desmond G. HIGGINS, Walter KOLCH, 2017. Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance. In: Genome Medicine. 2017, 9(1), 15. eISSN 1756-994X. Available under: doi: 10.1186/s13073-017-0407-3eng
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kops.sourcefield.plainGenome Medicine. 2017, 9(1), 15. eISSN 1756-994X. Available under: doi: 10.1186/s13073-017-0407-3eng
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source.bibliographicInfo.articleNumber15eng
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source.identifier.eissn1756-994Xeng
source.periodicalTitleGenome Medicineeng

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