Publikation:

Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance

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Duffy_0-399124.pdf
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Datum

2017

Autor:innen

Duffy, David J.
Krstic, Aleksandar
Halasz, Melinda
Schwarzl, Thomas
Iljin, Kristiina
Higgins, Desmond G.
Kolch, Walter

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-399124
DOI (zitierfähiger Link)
https://doi.org/10.1186/s13073-017-0407-3
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Published

Erschienen in

Genome Medicine. 2017, 9(1), 15. eISSN 1756-994X. Available under: doi: 10.1186/s13073-017-0407-3

Zusammenfassung

Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of cellular MYCN antagonises these signalling events to prevent differentiation and confer resistance.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

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ISO 690DUFFY, David J., Aleksandar KRSTIC, Melinda HALASZ, Thomas SCHWARZL, Anja KONIETZNY, Kristiina ILJIN, Desmond G. HIGGINS, Walter KOLCH, 2017. Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance. In: Genome Medicine. 2017, 9(1), 15. eISSN 1756-994X. Available under: doi: 10.1186/s13073-017-0407-3
BibTex
@article{Duffy2017Retin-38631,
  year={2017},
  doi={10.1186/s13073-017-0407-3},
  title={Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance},
  number={1},
  volume={9},
  journal={Genome Medicine},
  author={Duffy, David J. and Krstic, Aleksandar and Halasz, Melinda and Schwarzl, Thomas and Konietzny, Anja and Iljin, Kristiina and Higgins, Desmond G. and Kolch, Walter},
  note={Article Number: 15}
}
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