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Liver-on-a-Chip (LoC) Models : Case Studies of Academic Platforms and Commercial Products

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2026

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Benzait, Zineb
Tomsuk, Özlem
Ebrahimi, Aliakbar
Ghorbanpoor, Hamed
Özel, Ceren
Didarian, Reza
Demir Cevizlidere, Bahar
Kaya, Murat
Gasimzade, Nigar
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https://doi.org/10.1021/acs.molpharmaceut.5c01122
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Molecular Pharmaceutics. ACS Publications. ISSN 1543-8384. eISSN 1543-8392. Verfügbar unter: doi: 10.1021/acs.molpharmaceut.5c01122

Zusammenfassung

Pharmaceutical companies place significant importance on the liver due to its crucial role in numerous biochemical processes, specifically in drug metabolism. This focus has led to significant progress in liver-on-a-chip (LoC) technology, which has proven useful not only in drug development but also in more advanced applications. As a result, elaboration and incorporation of advanced LoC models into preclinical workflows have great potential to decrease R&D expenses and reduce or even replace animal testing, while improving the safety and efficacy of new therapies. To explore this potential, the present review provides an overview of recent academic and commercial LoC models, examines their different designs and cellular compositions, and evaluates the advantages and disadvantages of their complexity. A systematic comparison of these models is then performed, along with a discussion of their current challenges and future perspectives. Ultimately, we hope this review will assist scientists and industry professionals in selecting optimal models and in contributing to future advancements in LoC technology.

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570 Biowissenschaften, Biologie

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ISO 690BENZAIT, Zineb, Özlem TOMSUK, Aliakbar EBRAHIMI, Hamed GHORBANPOOR, Ceren ÖZEL, Reza DIDARIAN, Bahar DEMIR CEVIZLIDERE, Murat KAYA, Tamer GÜR, Nigar GASIMZADE, Fulya Büge ERGEN, Ahmet Emin TOPAL, Shadab DABAGH, Roshan JAVANIFAR, Nuran ABDULLAYEVA, Onur UYSAL, Ayla EKER SARIBOYACI, Fatma DOĞAN GÜZEL, Shabir HASSAN, Huseyin AVCI, 2026. Liver-on-a-Chip (LoC) Models : Case Studies of Academic Platforms and Commercial Products. In: Molecular Pharmaceutics. ACS Publications. ISSN 1543-8384. eISSN 1543-8392. Verfügbar unter: doi: 10.1021/acs.molpharmaceut.5c01122
BibTex
@article{Benzait2026-02-01Liver-76256,
  title={Liver-on-a-Chip (LoC) Models : Case Studies of Academic Platforms and Commercial Products},
  year={2026},
  doi={10.1021/acs.molpharmaceut.5c01122},
  issn={1543-8384},
  journal={Molecular Pharmaceutics},
  author={Benzait, Zineb and Tomsuk, Özlem and Ebrahimi, Aliakbar and Ghorbanpoor, Hamed and Özel, Ceren and Didarian, Reza and Demir Cevizlidere, Bahar and Kaya, Murat and Gür, Tamer and Gasimzade, Nigar and Ergen, Fulya Büge and Topal, Ahmet Emin and Dabagh, Shadab and Javanifar, Roshan and Abdullayeva, Nuran and Uysal, Onur and Eker Sarıboyacı, Ayla and Doğan Güzel, Fatma and Hassan, Shabir and Avci, Huseyin}
}
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