Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus

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dc.contributor.authorLünse, Christina E.deu
dc.contributor.authorSchmidt, Magnus S.
dc.contributor.authorWittmann, Valentin
dc.contributor.authorMayer, Günterdeu
dc.date.accessioned2012-05-11T07:43:02Zdeu
dc.date.available2012-05-11T07:43:02Zdeu
dc.date.issued2011-07-15
dc.description.abstractThe glmS-riboswitch is unique among riboswitch families as it represents a metabolite-dependent ribozyme that undergoes self-cleavage upon recognition of glucosamin-6-phosphate. The glmS-riboswitch is located in the 5′-untranslated region of bacterial genes involved in cell wall biosynthesis. Therefore, this riboswitch represents a promising target for developing new antibiotics. We describe the metabolite-dependent glmS-riboswitch of pathologically relevant and vancomycin-resistant Staphylococcus aureus and the discovery and synthesis of a carba-sugar with potency similar to that of the native metabolite glucosamine-6-phosphate in modulating riboswitch activity. This compound represents a valuable lead structure for the development of antibiotics with a novel mode of action.eng
dc.description.versionpublished
dc.identifier.citationPubl. in: ACS Chemical biology ; 6 (2011), 7. - S. 675-678deu
dc.identifier.doi10.1021/cb200016ddeu
dc.identifier.pmid21486059
dc.identifier.ppn370350588deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/19285
dc.language.isoengdeu
dc.legacy.dateIssued2012-05-11deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subject.ddc540deu
dc.titleCarba-sugars Activate the glmS-Riboswitch of Staphylococcus aureuseng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{Lunse2011-07-15Carba-19285,
  year={2011},
  doi={10.1021/cb200016d},
  title={Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus},
  number={7},
  volume={6},
  issn={1554-8929},
  journal={ACS Chemical Biology},
  pages={675--678},
  author={Lünse, Christina E. and Schmidt, Magnus S. and Wittmann, Valentin and Mayer, Günter}
}
kops.citation.iso690LÜNSE, Christina E., Magnus S. SCHMIDT, Valentin WITTMANN, Günter MAYER, 2011. Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus. In: ACS Chemical Biology. 2011, 6(7), pp. 675-678. ISSN 1554-8929. eISSN 1554-8937. Available under: doi: 10.1021/cb200016ddeu
kops.citation.iso690LÜNSE, Christina E., Magnus S. SCHMIDT, Valentin WITTMANN, Günter MAYER, 2011. Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus. In: ACS Chemical Biology. 2011, 6(7), pp. 675-678. ISSN 1554-8929. eISSN 1554-8937. Available under: doi: 10.1021/cb200016deng
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    <dcterms:abstract xml:lang="eng">The glmS-riboswitch is unique among riboswitch families as it represents a metabolite-dependent ribozyme that undergoes self-cleavage upon recognition of glucosamin-6-phosphate. The glmS-riboswitch is located in the 5′-untranslated region of bacterial genes involved in cell wall biosynthesis. Therefore, this riboswitch represents a promising target for developing new antibiotics. We describe the metabolite-dependent glmS-riboswitch of pathologically relevant and vancomycin-resistant Staphylococcus aureus and the discovery and synthesis of a carba-sugar with potency similar to that of the native metabolite glucosamine-6-phosphate in modulating riboswitch activity. This compound represents a valuable lead structure for the development of antibiotics with a novel mode of action.</dcterms:abstract>
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