Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus

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2011
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Lünse, Christina E.
Mayer, Günter
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ACS Chemical Biology. 2011, 6(7), pp. 675-678. ISSN 1554-8929. eISSN 1554-8937. Available under: doi: 10.1021/cb200016d
Zusammenfassung

The glmS-riboswitch is unique among riboswitch families as it represents a metabolite-dependent ribozyme that undergoes self-cleavage upon recognition of glucosamin-6-phosphate. The glmS-riboswitch is located in the 5′-untranslated region of bacterial genes involved in cell wall biosynthesis. Therefore, this riboswitch represents a promising target for developing new antibiotics. We describe the metabolite-dependent glmS-riboswitch of pathologically relevant and vancomycin-resistant Staphylococcus aureus and the discovery and synthesis of a carba-sugar with potency similar to that of the native metabolite glucosamine-6-phosphate in modulating riboswitch activity. This compound represents a valuable lead structure for the development of antibiotics with a novel mode of action.

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ISO 690LÜNSE, Christina E., Magnus S. SCHMIDT, Valentin WITTMANN, Günter MAYER, 2011. Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus. In: ACS Chemical Biology. 2011, 6(7), pp. 675-678. ISSN 1554-8929. eISSN 1554-8937. Available under: doi: 10.1021/cb200016d
BibTex
@article{Lunse2011-07-15Carba-19285,
  year={2011},
  doi={10.1021/cb200016d},
  title={Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus},
  number={7},
  volume={6},
  issn={1554-8929},
  journal={ACS Chemical Biology},
  pages={675--678},
  author={Lünse, Christina E. and Schmidt, Magnus S. and Wittmann, Valentin and Mayer, Günter}
}
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