Analysis and expression of a cloned pre-T cell receptor gene

Kurzanzeige
dc.contributor.authorSaint-Ruf, Claudedeu
dc.contributor.authorUngewiss, Katharinadeu
dc.contributor.authorGroettrup, Marcus
dc.contributor.authorBruno, Ludovicadeu
dc.contributor.authorFehling, Hans Jörgdeu
dc.contributor.authorBoehmer, Harald vondeu
dc.date.accessioned2011-03-23T09:07:26Zdeu
dc.date.available2011-03-23T09:07:26Zdeu
dc.date.issued2009deu
dc.description.abstractThe T cell antigen receptor (TCR) p chain regulates early T cell development in the absence of the TCRa chain. The developmentally controlled gene described here encodes the pre-TCRa (pTa) chain, which covalently associates with TCRp and with the CD3 proteins forms a pre-TCR complex that transduces signals in immature thymocytes. Unlike the λ5 pre-B cell receptor protein, the pTa chain is a type I transmembrane protein whose cytoplasmic tail contains two potential phosphorylation sites and a Src homology 3 (SH3)-domain binding sequence. Pre-TCRa transfection experiments indicated that surface expression of the pre-TCR is controlled by additional developmentally regulated proteins. Identification of the pTa gene represents an essential step in the structure-function analysis of the pre-TCR complex.eng
dc.description.versionpublished
dc.identifier.citationPubl. in: The Journal of Immunology 182 (2009), 9, pp. 5165-5169deu
dc.identifier.urihttp://kops.uni-konstanz.de/handle/123456789/1252
dc.language.isoengdeu
dc.legacy.dateIssued2010deu
dc.rightsterms-of-usedeu
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/deu
dc.subject.ddc570deu
dc.titleAnalysis and expression of a cloned pre-T cell receptor geneeng
dc.typeJOURNAL_ARTICLEdeu
dspace.entity.typePublication
kops.citation.bibtex
@article{SaintRuf2009Analy-1252,
  year={2009},
  title={Analysis and expression of a cloned pre-T cell receptor gene},
  number={9},
  volume={182},
  journal={The Journal of Immunology},
  pages={5165--5169},
  author={Saint-Ruf, Claude and Ungewiss, Katharina and Gröttrup, Marcus and Bruno, Ludovica and Fehling, Hans Jörg and Boehmer, Harald von}
}
kops.citation.iso690SAINT-RUF, Claude, Katharina UNGEWISS, Marcus GRÖTTRUP, Ludovica BRUNO, Hans Jörg FEHLING, Harald von BOEHMER, 2009. Analysis and expression of a cloned pre-T cell receptor gene. In: The Journal of Immunology. 2009, 182(9), pp. 5165-5169deu
kops.citation.iso690SAINT-RUF, Claude, Katharina UNGEWISS, Marcus GRÖTTRUP, Ludovica BRUNO, Hans Jörg FEHLING, Harald von BOEHMER, 2009. Analysis and expression of a cloned pre-T cell receptor gene. In: The Journal of Immunology. 2009, 182(9), pp. 5165-5169eng
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