Analysis and expression of a cloned pre-T cell receptor gene

Saint-Ruf, Claude; Ungewiss, Katharina; Gröttrup, Marcus; Bruno, Ludovica; Fehling, Hans Jörg; Boehmer, Harald von

Analysis and expression of a cloned pre-T cell receptor gene

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Date

2009

Authors

Saint-Ruf, Claude

Ungewiss, Katharina

Gröttrup, Marcus

Bruno, Ludovica

Fehling, Hans Jörg

Boehmer, Harald von

Publication type

Journal article

Published in

The Journal of Immunology ; 182 (2009), 9. - pp. 5165-5169

Abstract

The T cell antigen receptor (TCR) p chain regulates early T cell development in the absence of the TCRa chain. The developmentally controlled gene described here encodes the pre-TCRa (pTa) chain, which covalently associates with TCRp and with the CD3 proteins forms a pre-TCR complex that transduces signals in immature thymocytes. Unlike the λ5 pre-B cell receptor protein, the pTa chain is a type I transmembrane protein whose cytoplasmic tail contains two potential phosphorylation sites and a Src homology 3 (SH3)-domain binding sequence. Pre-TCRa transfection experiments indicated that surface expression of the pre-TCR is controlled by additional developmentally regulated proteins. Identification of the pTa gene represents an essential step in the structure-function analysis of the pre-TCR complex.

Subject (DDC)

570 Biosciences, Biology

Cite This

ISO 690

SAINT-RUF, Claude, Katharina UNGEWISS, Marcus GRÖTTRUP, Ludovica BRUNO, Hans Jörg FEHLING, Harald von BOEHMER, 2009. Analysis and expression of a cloned pre-T cell receptor gene. In: The Journal of Immunology. 182(9), pp. 5165-5169

BibTex

@article{SaintRuf2009Analy-1252,
  year={2009},
  title={Analysis and expression of a cloned pre-T cell receptor gene},
  number={9},
  volume={182},
  journal={The Journal of Immunology},
  pages={5165--5169},
  author={Saint-Ruf, Claude and Ungewiss, Katharina and Gröttrup, Marcus and Bruno, Ludovica and Fehling, Hans Jörg and Boehmer, Harald von}
}

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