Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System

Kurzanzeige
dc.contributor.authorAutrup, Herman
dc.contributor.authorBarile, Frank A.
dc.contributor.authorBlaauboer, Bas J.
dc.contributor.authorDegen, Gisela H.
dc.contributor.authorDekant, Wolfgang
dc.contributor.authorDietrich, Daniel R.
dc.contributor.authorDomingo, Jose L.
dc.contributor.authorGori, Gio Batta
dc.contributor.authorGreim, Helmuth
dc.contributor.authorHengstler, Jan G.
dc.contributor.authorKacew, Sam
dc.contributor.authorMarquardt, Hans
dc.contributor.authorPelkonen, Olavi
dc.contributor.authorSavolainen, Kai
dc.contributor.authorVermeulen, Nico P.
dc.date.accessioned2016-03-01T13:14:31Z
dc.date.available2016-03-01T13:14:31Z
dc.date.issued2015eng
dc.description.abstractThe present debate on chemicals with Hormonal activity, often termed `endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1093/toxsci/kfv082eng
dc.identifier.ppn474971570
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/33158
dc.language.isoengeng
dc.rightsterms-of-use
dc.rights.urihttps://rightsstatements.org/page/InC/1.0/
dc.subjectendocrine disruptors, endocrine toxicology, risk assessment, regulatory/policy, risk assessmenteng
dc.subject.ddc570eng
dc.titlePrinciples of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine Systemeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Autrup2015Princ-33158,
  year={2015},
  doi={10.1093/toxsci/kfv082},
  title={Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System},
  number={1},
  volume={146},
  issn={1096-6080},
  journal={Toxicological Sciences},
  pages={11--15},
  author={Autrup, Herman and Barile, Frank A. and Blaauboer, Bas J. and Degen, Gisela H. and Dekant, Wolfgang and Dietrich, Daniel R. and Domingo, Jose L. and Gori, Gio Batta and Greim, Helmuth and Hengstler, Jan G. and Kacew, Sam and Marquardt, Hans and Pelkonen, Olavi and Savolainen, Kai and Vermeulen, Nico P.}
}
kops.citation.iso690AUTRUP, Herman, Frank A. BARILE, Bas J. BLAAUBOER, Gisela H. DEGEN, Wolfgang DEKANT, Daniel R. DIETRICH, Jose L. DOMINGO, Gio Batta GORI, Helmuth GREIM, Jan G. HENGSTLER, Sam KACEW, Hans MARQUARDT, Olavi PELKONEN, Kai SAVOLAINEN, Nico P. VERMEULEN, 2015. Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System. In: Toxicological Sciences. 2015, 146(1), pp. 11-15. ISSN 1096-6080. eISSN 1096-0929. Available under: doi: 10.1093/toxsci/kfv082deu
kops.citation.iso690AUTRUP, Herman, Frank A. BARILE, Bas J. BLAAUBOER, Gisela H. DEGEN, Wolfgang DEKANT, Daniel R. DIETRICH, Jose L. DOMINGO, Gio Batta GORI, Helmuth GREIM, Jan G. HENGSTLER, Sam KACEW, Hans MARQUARDT, Olavi PELKONEN, Kai SAVOLAINEN, Nico P. VERMEULEN, 2015. Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System. In: Toxicological Sciences. 2015, 146(1), pp. 11-15. ISSN 1096-6080. eISSN 1096-0929. Available under: doi: 10.1093/toxsci/kfv082eng
kops.citation.rdf
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/33158">
    <dc:creator>Pelkonen, Olavi</dc:creator>
    <dc:contributor>Dekant, Wolfgang</dc:contributor>
    <dc:contributor>Domingo, Jose L.</dc:contributor>
    <dc:contributor>Autrup, Herman</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Hengstler, Jan G.</dc:creator>
    <dc:contributor>Dietrich, Daniel R.</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-03-01T13:14:31Z</dc:date>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Kacew, Sam</dc:contributor>
    <dc:creator>Greim, Helmuth</dc:creator>
    <dc:contributor>Greim, Helmuth</dc:contributor>
    <dcterms:issued>2015</dcterms:issued>
    <dc:creator>Dietrich, Daniel R.</dc:creator>
    <dc:contributor>Savolainen, Kai</dc:contributor>
    <dc:creator>Vermeulen, Nico P.</dc:creator>
    <dc:creator>Kacew, Sam</dc:creator>
    <dc:creator>Autrup, Herman</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33158/3/Dietrich_0-302404.pdf"/>
    <dc:creator>Blaauboer, Bas J.</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-03-01T13:14:31Z</dcterms:available>
    <dcterms:title>Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System</dcterms:title>
    <dc:creator>Marquardt, Hans</dc:creator>
    <dc:creator>Dekant, Wolfgang</dc:creator>
    <dc:creator>Degen, Gisela H.</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:rights>terms-of-use</dc:rights>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33158/3/Dietrich_0-302404.pdf"/>
    <dc:contributor>Marquardt, Hans</dc:contributor>
    <dc:creator>Savolainen, Kai</dc:creator>
    <dc:creator>Domingo, Jose L.</dc:creator>
    <dcterms:abstract xml:lang="eng">The present debate on chemicals with Hormonal activity, often termed `endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.</dcterms:abstract>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/33158"/>
    <dc:contributor>Hengstler, Jan G.</dc:contributor>
    <dc:contributor>Blaauboer, Bas J.</dc:contributor>
    <dc:creator>Barile, Frank A.</dc:creator>
    <dc:contributor>Vermeulen, Nico P.</dc:contributor>
    <dc:creator>Gori, Gio Batta</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Pelkonen, Olavi</dc:contributor>
    <dc:contributor>Degen, Gisela H.</dc:contributor>
    <dc:contributor>Barile, Frank A.</dc:contributor>
    <dc:contributor>Gori, Gio Batta</dc:contributor>
  </rdf:Description>
</rdf:RDF>
kops.description.openAccessopenaccessgreen
kops.flag.knbibliographytrue
kops.identifier.nbnurn:nbn:de:bsz:352-0-302404
kops.sourcefieldToxicological Sciences. 2015, <b>146</b>(1), pp. 11-15. ISSN 1096-6080. eISSN 1096-0929. Available under: doi: 10.1093/toxsci/kfv082deu
kops.sourcefield.plainToxicological Sciences. 2015, 146(1), pp. 11-15. ISSN 1096-6080. eISSN 1096-0929. Available under: doi: 10.1093/toxsci/kfv082deu
kops.sourcefield.plainToxicological Sciences. 2015, 146(1), pp. 11-15. ISSN 1096-6080. eISSN 1096-0929. Available under: doi: 10.1093/toxsci/kfv082eng
relation.isAuthorOfPublication1bbf5832-2b75-4182-ad74-4fcde1d6c6ca
relation.isAuthorOfPublication.latestForDiscovery1bbf5832-2b75-4182-ad74-4fcde1d6c6ca
source.bibliographicInfo.fromPage11eng
source.bibliographicInfo.issue1eng
source.bibliographicInfo.toPage15eng
source.bibliographicInfo.volume146eng
source.identifier.eissn1096-0929eng
source.identifier.issn1096-6080eng
source.periodicalTitleToxicological Scienceseng
temp.internal.duplicates<p>Keine Dubletten gefunden. Letzte Überprüfung: 08.10.2015 12:28:55</p>deu

Dateien

Originalbündel

Gerade angezeigt 1 - 1 von 1
Vorschaubild nicht verfügbar
Name:
Dietrich_0-302404.pdf
Größe:
66.22 KB
Format:
Adobe Portable Document Format
Beschreibung:
Dietrich_0-302404.pdf
Dietrich_0-302404.pdfGröße: 66.22 KBDownloads: 281

Lizenzbündel

Gerade angezeigt 1 - 1 von 1
Vorschaubild nicht verfügbar
Name:
license.txt
Größe:
3.88 KB
Format:
Item-specific license agreed upon to submission
Beschreibung:
license.txt
license.txtGröße: 3.88 KBDownloads: 0

Sammlungen

Biologie: Publikationen