Publikation: Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System
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Datum
2015
Autor:innen
Autrup, Herman
Barile, Frank A.
Blaauboer, Bas J.
Degen, Gisela H.
Dekant, Wolfgang
Domingo, Jose L.
Gori, Gio Batta
Greim, Helmuth
Hengstler, Jan G.
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Published
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Toxicological Sciences. 2015, 146(1), pp. 11-15. ISSN 1096-6080. eISSN 1096-0929. Available under: doi: 10.1093/toxsci/kfv082
Zusammenfassung
The present debate on chemicals with Hormonal activity, often termed `endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
endocrine disruptors, endocrine toxicology, risk assessment, regulatory/policy, risk assessment
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AUTRUP, Herman, Frank A. BARILE, Bas J. BLAAUBOER, Gisela H. DEGEN, Wolfgang DEKANT, Daniel R. DIETRICH, Jose L. DOMINGO, Gio Batta GORI, Helmuth GREIM, Jan G. HENGSTLER, Sam KACEW, Hans MARQUARDT, Olavi PELKONEN, Kai SAVOLAINEN, Nico P. VERMEULEN, 2015. Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System. In: Toxicological Sciences. 2015, 146(1), pp. 11-15. ISSN 1096-6080. eISSN 1096-0929. Available under: doi: 10.1093/toxsci/kfv082BibTex
@article{Autrup2015Princ-33158,
year={2015},
doi={10.1093/toxsci/kfv082},
title={Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System},
number={1},
volume={146},
issn={1096-6080},
journal={Toxicological Sciences},
pages={11--15},
author={Autrup, Herman and Barile, Frank A. and Blaauboer, Bas J. and Degen, Gisela H. and Dekant, Wolfgang and Dietrich, Daniel R. and Domingo, Jose L. and Gori, Gio Batta and Greim, Helmuth and Hengstler, Jan G. and Kacew, Sam and Marquardt, Hans and Pelkonen, Olavi and Savolainen, Kai and Vermeulen, Nico P.}
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<dcterms:abstract xml:lang="eng">The present debate on chemicals with Hormonal activity, often termed `endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.</dcterms:abstract>
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