Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System
Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System
Loading...
Date
2015
Authors
Autrup, Herman
Barile, Frank A.
Blaauboer, Bas J.
Degen, Gisela H.
Dekant, Wolfgang
Domingo, Jose L.
Gori, Gio Batta
Greim, Helmuth
Hengstler, Jan G.
Editors
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
URI (citable link)
DOI (citable link)
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Title in another language
Publication type
Journal article
Publication status
Published
Published in
Toxicological Sciences ; 146 (2015), 1. - pp. 11-15. - ISSN 1096-6080. - eISSN 1096-0929
Abstract
The present debate on chemicals with Hormonal activity, often termed `endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.
Summary in another language
Subject (DDC)
570 Biosciences, Biology
Keywords
endocrine disruptors, endocrine toxicology, risk assessment, regulatory/policy, risk assessment
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690
AUTRUP, Herman, Frank A. BARILE, Bas J. BLAAUBOER, Gisela H. DEGEN, Wolfgang DEKANT, Daniel R. DIETRICH, Jose L. DOMINGO, Gio Batta GORI, Helmuth GREIM, Jan G. HENGSTLER, Sam KACEW, Hans MARQUARDT, Olavi PELKONEN, Kai SAVOLAINEN, Nico P. VERMEULEN, 2015. Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System. In: Toxicological Sciences. 146(1), pp. 11-15. ISSN 1096-6080. eISSN 1096-0929. Available under: doi: 10.1093/toxsci/kfv082BibTex
@article{Autrup2015Princ-33158, year={2015}, doi={10.1093/toxsci/kfv082}, title={Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System}, number={1}, volume={146}, issn={1096-6080}, journal={Toxicological Sciences}, pages={11--15}, author={Autrup, Herman and Barile, Frank A. and Blaauboer, Bas J. and Degen, Gisela H. and Dekant, Wolfgang and Dietrich, Daniel R. and Domingo, Jose L. and Gori, Gio Batta and Greim, Helmuth and Hengstler, Jan G. and Kacew, Sam and Marquardt, Hans and Pelkonen, Olavi and Savolainen, Kai and Vermeulen, Nico P.} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/33158"> <dc:creator>Pelkonen, Olavi</dc:creator> <dc:contributor>Dekant, Wolfgang</dc:contributor> <dc:contributor>Domingo, Jose L.</dc:contributor> <dc:contributor>Autrup, Herman</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dc:creator>Hengstler, Jan G.</dc:creator> <dc:contributor>Dietrich, Daniel R.</dc:contributor> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-03-01T13:14:31Z</dc:date> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Kacew, Sam</dc:contributor> <dc:creator>Greim, Helmuth</dc:creator> <dc:contributor>Greim, Helmuth</dc:contributor> <dcterms:issued>2015</dcterms:issued> <dc:creator>Dietrich, Daniel R.</dc:creator> <dc:contributor>Savolainen, Kai</dc:contributor> <dc:creator>Vermeulen, Nico P.</dc:creator> <dc:creator>Kacew, Sam</dc:creator> <dc:creator>Autrup, Herman</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33158/3/Dietrich_0-302404.pdf"/> <dc:creator>Blaauboer, Bas J.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-03-01T13:14:31Z</dcterms:available> <dcterms:title>Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System</dcterms:title> <dc:creator>Marquardt, Hans</dc:creator> <dc:creator>Dekant, Wolfgang</dc:creator> <dc:creator>Degen, Gisela H.</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:rights>terms-of-use</dc:rights> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/33158/3/Dietrich_0-302404.pdf"/> <dc:contributor>Marquardt, Hans</dc:contributor> <dc:creator>Savolainen, Kai</dc:creator> <dc:creator>Domingo, Jose L.</dc:creator> <dcterms:abstract xml:lang="eng">The present debate on chemicals with Hormonal activity, often termed `endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.</dcterms:abstract> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/33158"/> <dc:contributor>Hengstler, Jan G.</dc:contributor> <dc:contributor>Blaauboer, Bas J.</dc:contributor> <dc:creator>Barile, Frank A.</dc:creator> <dc:contributor>Vermeulen, Nico P.</dc:contributor> <dc:creator>Gori, Gio Batta</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Pelkonen, Olavi</dc:contributor> <dc:contributor>Degen, Gisela H.</dc:contributor> <dc:contributor>Barile, Frank A.</dc:contributor> <dc:contributor>Gori, Gio Batta</dc:contributor> </rdf:Description> </rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
Yes