Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo
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2006
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Mennini, Tiziana
Paola, Massimiliano de
Bigini, Paolo
Mastrotto, Cristina
Fumagalli, Elena
Barbera, Sara
Mengozzi, Manuela
Viviani, Barbara
Corsini, Emanuela
Marinovich, Marina
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Molecular Medicine. 2006, 12(7/8), pp. 153-160. ISSN 1076-1551. eISSN 1528-3658. Available under: doi: 10.2119/2006-00045.Mennini
Zusammenfassung
Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the cervical spinal cord of wobbler mice, an animal model of amyotrophic lateral sclerosis, but had no effect on hematocrit values. ASIALO-EPO and CEPO, like the parent compound EPO, protected primary motoneuron cultures from kainate-induced death in vitro. Both EPO receptor and the common CD131 β chain were expressed in cultured motoneurons and in the anterior horn of wobbler mice spinal cord. Our results strongly support a role for the common β chain CD131 in the protective effect of EPO derivatives on motoneuron degeneration. Thus CEPO, which does not bind to the classical homodimeric EPO receptor and is devoid of hematopoietic activity, could be effective in chronic treatment aimed at reducing motoneuron degeneration.
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MENNINI, Tiziana, Massimiliano de PAOLA, Paolo BIGINI, Cristina MASTROTTO, Elena FUMAGALLI, Sara BARBERA, Manuela MENGOZZI, Barbara VIVIANI, Emanuela CORSINI, Marina MARINOVICH, Lars TORUP, Johan van BEEK, Marcel LEIST, Michael BRINES, Anthony CERAMI, Pietro GHEZZI, 2006. Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo. In: Molecular Medicine. 2006, 12(7/8), pp. 153-160. ISSN 1076-1551. eISSN 1528-3658. Available under: doi: 10.2119/2006-00045.MenniniBibTex
@article{Mennini2006Nonhe-7862,
year={2006},
doi={10.2119/2006-00045.Mennini},
title={Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo},
number={7/8},
volume={12},
issn={1076-1551},
journal={Molecular Medicine},
pages={153--160},
author={Mennini, Tiziana and Paola, Massimiliano de and Bigini, Paolo and Mastrotto, Cristina and Fumagalli, Elena and Barbera, Sara and Mengozzi, Manuela and Viviani, Barbara and Corsini, Emanuela and Marinovich, Marina and Torup, Lars and Beek, Johan van and Leist, Marcel and Brines, Michael and Cerami, Anthony and Ghezzi, Pietro}
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<dcterms:abstract xml:lang="eng">Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the cervical spinal cord of wobbler mice, an animal model of amyotrophic lateral sclerosis, but had no effect on hematocrit values. ASIALO-EPO and CEPO, like the parent compound EPO, protected primary motoneuron cultures from kainate-induced death in vitro. Both EPO receptor and the common CD131 β chain were expressed in cultured motoneurons and in the anterior horn of wobbler mice spinal cord. Our results strongly support a role for the common β chain CD131 in the protective effect of EPO derivatives on motoneuron degeneration. Thus CEPO, which does not bind to the classical homodimeric EPO receptor and is devoid of hematopoietic activity, could be effective in chronic treatment aimed at reducing motoneuron degeneration.</dcterms:abstract>
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