Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma

Kurzanzeige
dc.contributor.authorBarra, Lena
dc.contributor.authorDickschat, Jeroen S.
dc.date.accessioned2022-05-17T09:17:18Z
dc.date.available2022-05-17T09:17:18Z
dc.date.issued2017eng
dc.description.abstractAnalysis of the volatile terpenes produced by seven fungal strains of the genus Trichoderma by use of a closed-loop stripping apparatus (CLSA) revealed a common production of harzianone, a bioactive, structurally unique diterpenoid consisting of a fused tetracyclic 4,7,5,6-membered ring system. The terpene cyclization mechanism was studied by feeding experiments using selectively 13C- and 2H-labeled synthetic mevalonolactone isotopologues, followed by analysis of the incorporation patterns by 13C NMR spectroscopy and GC/MS. The structure of harzianone was further supported from a 13C,13C COSY experiment of the in-vivo-generated fully 13C-labeled diterpene.eng
dc.description.versionpublishedeng
dc.identifier.doi10.1002/cbic.201700462eng
dc.identifier.pmid28944564eng
dc.identifier.ppn1841629553
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/57553
dc.language.isoengeng
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dc.subject.ddc540eng
dc.titleHarzianone Biosynthesis by the Biocontrol Fungus Trichodermaeng
dc.typeJOURNAL_ARTICLEeng
dspace.entity.typePublication
kops.citation.bibtex
@article{Barra2017Harzi-57553,
  year={2017},
  doi={10.1002/cbic.201700462},
  title={Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma},
  number={23},
  volume={18},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2358--2365},
  author={Barra, Lena and Dickschat, Jeroen S.}
}
kops.citation.iso690BARRA, Lena, Jeroen S. DICKSCHAT, 2017. Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma. In: ChemBioChem. Wiley-VCH. 2017, 18(23), pp. 2358-2365. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201700462deu
kops.citation.iso690BARRA, Lena, Jeroen S. DICKSCHAT, 2017. Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma. In: ChemBioChem. Wiley-VCH. 2017, 18(23), pp. 2358-2365. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201700462eng
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source.periodicalTitleChemBioChemeng
source.publisherWiley-VCHeng

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