Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma

Barra, Lena; Dickschat, Jeroen S.

Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma

Dateien

Barra_2-2lj3q99eszu43.pdf(494.7 KB)

Datum

2017

Autor:innen

Barra, Lena

Dickschat, Jeroen S.

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

ChemBioChem ; 18 (2017), 23. - S. 2358-2365. - Wiley-VCH. - ISSN 1439-4227. - eISSN 1439-7633

Zusammenfassung

Analysis of the volatile terpenes produced by seven fungal strains of the genus Trichoderma by use of a closed-loop stripping apparatus (CLSA) revealed a common production of harzianone, a bioactive, structurally unique diterpenoid consisting of a fused tetracyclic 4,7,5,6-membered ring system. The terpene cyclization mechanism was studied by feeding experiments using selectively ¹³C- and ²H-labeled synthetic mevalonolactone isotopologues, followed by analysis of the incorporation patterns by ¹³C NMR spectroscopy and GC/MS. The structure of harzianone was further supported from a ¹³C,¹³C COSY experiment of the in-vivo-generated fully ¹³C-labeled diterpene.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

BARRA, Lena, Jeroen S. DICKSCHAT, 2017. Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma. In: ChemBioChem. Wiley-VCH. 18(23), pp. 2358-2365. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201700462

BibTex

@article{Barra2017Harzi-57553,
  year={2017},
  doi={10.1002/cbic.201700462},
  title={Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma},
  number={23},
  volume={18},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2358--2365},
  author={Barra, Lena and Dickschat, Jeroen S.}
}

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