Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma

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2017
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Dickschat, Jeroen S.
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Analysis of the volatile terpenes produced by seven fungal strains of the genus Trichoderma by use of a closed-loop stripping apparatus (CLSA) revealed a common production of harzianone, a bioactive, structurally unique diterpenoid consisting of a fused tetracyclic 4,7,5,6-membered ring system. The terpene cyclization mechanism was studied by feeding experiments using selectively 13C- and 2H-labeled synthetic mevalonolactone isotopologues, followed by analysis of the incorporation patterns by 13C NMR spectroscopy and GC/MS. The structure of harzianone was further supported from a 13C,13C COSY experiment of the in-vivo-generated fully 13C-labeled diterpene.

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ISO 690BARRA, Lena, Jeroen S. DICKSCHAT, 2017. Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma. In: ChemBioChem. Wiley-VCH. 2017, 18(23), pp. 2358-2365. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201700462
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@article{Barra2017Harzi-57553,
  year={2017},
  doi={10.1002/cbic.201700462},
  title={Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma},
  number={23},
  volume={18},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={2358--2365},
  author={Barra, Lena and Dickschat, Jeroen S.}
}
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