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Potential of colony-stimulating factors to improve host defense in organ transplant recipients

Potential of colony-stimulating factors to improve host defense in organ transplant recipients

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Prüfsumme: MD5:b01b22acab65b155acd2df59118799c9

XU, Jian, Sonja von AULOCK, Rudolf LUCAS, Albrecht WENDEL, 2004. Potential of colony-stimulating factors to improve host defense in organ transplant recipients. In: Current Opinion in Organ Transplantation. 9(4), pp. 411-417. ISSN 1087-2418. Available under: doi: 10.1097/01.mot.0000146562.43151.e4

@article{Xu2004Poten-8298, title={Potential of colony-stimulating factors to improve host defense in organ transplant recipients}, year={2004}, doi={10.1097/01.mot.0000146562.43151.e4}, number={4}, volume={9}, issn={1087-2418}, journal={Current Opinion in Organ Transplantation}, pages={411--417}, author={Xu, Jian and Aulock, Sonja von and Lucas, Rudolf and Wendel, Albrecht} }

Lucas, Rudolf Xu, Jian 2011-03-24T17:42:29Z deposit-license Potential of colony-stimulating factors to improve host defense in organ transplant recipients 2011-03-24T17:42:29Z First publ. in: Current Opinion in Organ Transplantation 9 (2004), pp. 411-417 Wendel, Albrecht eng Wendel, Albrecht Aulock, Sonja von Purpose of review:<br />Although immunosuppressive drugs prevent graft rejection, they also predispose patients to infection, representing a major complication in organ transplantation. It would thus be highly desirable to attain true immune tolerance without increasing the risk of infections and malignancies. Before the background of current strategies in the management of infections, the novel concept of differential reactivation of immunity, ie, boosting the innate immune response while continuing suppression of the adaptive immune response, is introduced.<br /><br />Recent findings:<br />Present clinical experience, feasibility, and potential risks of applying factors that potentially display such dichotomal properties (eg, granulocyte colony-stimulating factor [G-CSF] or granulocyte-macrophage colony-stimulating factor [GM-CSF]) are discussed.<br /><br />Summary:<br />In dexamethasone-treated PBMC isolated from control patients, or in cells obtained from immunosuppressed liver transplant patients, GM-CSF was found to selectively restore the innate immune response, without activating the specific immune response implicated in graft rejection. Moreover, GM-CSF efficiently restored the immune response against an otherwise lethal bacterial infection in immunosuppressed mice, without inducing the rejection of a skin transplant. These recent data could have implications for clinical practice and suggest a more detailed evaluation of agents with similar actions to GM-CSF in the restoration of innate immunity in organ transplant patients. Aulock, Sonja von Lucas, Rudolf 2004 application/pdf Xu, Jian

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