Trans-species polymorphism of class II Mhc loci in danio fishes

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GRASER, Robert, Colm O HUIGIN, Vladimir VINCEK, Axel MEYER, Jan KLEIN, 1996. Trans-species polymorphism of class II Mhc loci in danio fishes. In: Immunogenetics. 44(1), pp. 36-48. ISSN 0093-7711. eISSN 1432-1211. Available under: doi: 10.1007/BF02602655

@article{Graser1996Trans-7904, title={Trans-species polymorphism of class II Mhc loci in danio fishes}, year={1996}, doi={10.1007/BF02602655}, number={1}, volume={44}, issn={0093-7711}, journal={Immunogenetics}, pages={36--48}, author={Graser, Robert and O hUigin, Colm and Vincek, Vladimir and Meyer, Axel and Klein, Jan} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:bibliographicCitation>First publ. in: Immunogenetics 44 (1996), 1, pp. 36 48</dcterms:bibliographicCitation> <dc:contributor>Vincek, Vladimir</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Graser, Robert</dc:contributor> <dc:contributor>Meyer, Axel</dc:contributor> <dc:contributor>O hUigin, Colm</dc:contributor> <dcterms:title>Trans-species polymorphism of class II Mhc loci in danio fishes</dcterms:title> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">A characteristic feature of the major histocompatibility complex (Mhc) polymorphism in mammals is the existence of allelic lineages shared by related species. This trans-species polymorphism has thus far been documented only in primates, rodents, and artiodactyls. In this communication we provide evidence that it also exists in cyprinid (bony) fishes at the class II A and B loci coding for the a and b polypeptide chains of the class II a:b heterodimers. The study has focused on three species of the family Cyprinidae, subfamily Rasborinae: the zebrafish (Danio rerio), the giant danio (D. malabaricus), and the pearl danio (D. albolineatus). The polymerase chain reaction was used to amplify and then sequence intron 1 and exon 2 of the class II B loci and exon 2 of the class II A loci in these species. Phylogenetic analysis of the sequences revealed the existence of allelic lineages whose divergence predates the divergence of the three species at both the A and B loci. The lineages at the B locus in particular are separated by large genetic distances. The polymorphism is concentrated in the peptide-binding region sites and is apparently maintained by balancing selection. Sharing of this unique Mhc feature by both bony fishes and mammals suggests that the main function of the Mhc (presentation of peptides to T lymphocytes) has not changed during the last 400 million years of its evolution.</dcterms:abstract> <dc:creator>Vincek, Vladimir</dc:creator> <dc:date rdf:datatype="">2011-03-24T17:38:24Z</dc:date> <bibo:uri rdf:resource=""/> <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights> <dc:format>application/pdf</dc:format> <dc:creator>Klein, Jan</dc:creator> <dspace:hasBitstream rdf:resource=""/> <dc:contributor>Klein, Jan</dc:contributor> <dcterms:available rdf:datatype="">2011-03-24T17:38:24Z</dcterms:available> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:hasPart rdf:resource=""/> <dcterms:issued>1996</dcterms:issued> <dc:creator>O hUigin, Colm</dc:creator> <dc:creator>Graser, Robert</dc:creator> <dcterms:rights rdf:resource=""/> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Meyer, Axel</dc:creator> </rdf:Description> </rdf:RDF>

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