In vivo Olefin Metathesis in Microalgae Upgrades Lipids to Building Blocks for Polymers and Chemicals

Thumbnail Image
Date
2022
Editors
Contact
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
DOI (citable link)
ArXiv-ID
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Restricted until
Title in another language
Research Projects
Organizational Units
Journal Issue
Publication type
Journal article
Publication status
Published
Published in
Angewandte Chemie International Edition ; 61 (2022), 44. - e202211285. - Wiley. - ISSN 1521-3773. - eISSN 1521-3773
Abstract
Sustainable sources are key to future chemicals production. Microalgae are promising renewable resources as they fixate atmospheric carbon dioxide to organic molecules by photosynthesis, with sunlight as energy. Thereby they produce unsaturated fatty acids as established raw materials for the industrial production of chemical building blocks. Although these renewable feedstocks are generated inside cells, their synthetic catalytic upgrading to useful products requires ex vivo transformations. A synthetic catalysis inside living photoautotrophic cells has remained elusive. Here we show that a catalytic conversion of renewable substrates can be realized directly inside living microalgae. Organometallic catalysts are internalized and remain active inside the photoautotrophic cells, enabling in vivo catalytic olefin metathesis as new-to-nature transformation. Stored lipids are converted in vivo to alkenes and long-chain dicarboxylates as valuable building blocks for polymers. This is a key step towards the long-term goal of producing desired renewable chemicals in microalgae as living "cellular factories".
Summary in another language
Subject (DDC)
540 Chemistry
Keywords
Catalysis, Homogeneous Catalysis, Polymers, Renewable Resources, Sustainable Chemistry
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690SCHUNCK, Natalie S., Stefan MECKING, 2022. In vivo Olefin Metathesis in Microalgae Upgrades Lipids to Building Blocks for Polymers and Chemicals. In: Angewandte Chemie International Edition. Wiley. 61(44), e202211285. ISSN 1521-3773. eISSN 1521-3773. Available under: doi: 10.1002/anie.202211285
BibTex
@article{Schunck2022-11-02Olefi-58575,
  year={2022},
  doi={10.1002/anie.202211285},
  title={In vivo Olefin Metathesis in Microalgae Upgrades Lipids to Building Blocks for Polymers and Chemicals},
  number={44},
  volume={61},
  issn={1521-3773},
  journal={Angewandte Chemie International Edition},
  author={Schunck, Natalie S. and Mecking, Stefan},
  note={Article Number: e202211285}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/58575">
    <dcterms:issued>2022-11-02</dcterms:issued>
    <dc:rights>terms-of-use</dc:rights>
    <dc:language>eng</dc:language>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-08T13:52:43Z</dcterms:available>
    <dc:contributor>Mecking, Stefan</dc:contributor>
    <dc:creator>Mecking, Stefan</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/58575/1/Schunck_2-1m03spkod7x260.pdf"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/58575/1/Schunck_2-1m03spkod7x260.pdf"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dcterms:title>In vivo Olefin Metathesis in Microalgae Upgrades Lipids to Building Blocks for Polymers and Chemicals</dcterms:title>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/58575"/>
    <dc:creator>Schunck, Natalie S.</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Schunck, Natalie S.</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-08T13:52:43Z</dc:date>
    <dcterms:abstract xml:lang="eng">Sustainable sources are key to future chemicals production. Microalgae are promising renewable resources as they fixate atmospheric carbon dioxide to organic molecules by photosynthesis, with sunlight as energy. Thereby they produce unsaturated fatty acids as established raw materials for the industrial production of chemical building blocks. Although these renewable feedstocks are generated inside cells, their synthetic catalytic upgrading to useful products requires ex vivo transformations. A synthetic catalysis inside living photoautotrophic cells has remained elusive. Here we show that a catalytic conversion of renewable substrates can be realized directly inside living microalgae. Organometallic catalysts are internalized and remain active inside the photoautotrophic cells, enabling in vivo catalytic olefin metathesis as new-to-nature transformation. Stored lipids are converted in vivo to alkenes and long-chain dicarboxylates as valuable building blocks for polymers. This is a key step towards the long-term goal of producing desired renewable chemicals in microalgae as living "cellular factories".</dcterms:abstract>
  </rdf:Description>
</rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Contact
URL of original publication
Test date of URL
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
Yes
Refereed
Yes