@article{Walther2022Alpha-58307,
  year={2022},
  doi={10.3389/fendo.2022.824616},
  title={Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension},
  volume={13},
  journal={Frontiers in endocrinology},
  author={Walther, Lisa-Marie and von Känel, Roland and Heimgartner, Nadja and Zuccarella-Hackl, Claudia and Stirnimann, Guido and Wirtz, Petra H.},
  note={Article Number: 824616}
}

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    <dc:creator>Zuccarella-Hackl, Claudia</dc:creator>
    <dc:contributor>Stirnimann, Guido</dc:contributor>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-08-16T12:42:03Z</dc:date>
    <dc:creator>Walther, Lisa-Marie</dc:creator>
    <dc:contributor>Walther, Lisa-Marie</dc:contributor>
    <dc:contributor>Zuccarella-Hackl, Claudia</dc:contributor>
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    <dc:contributor>Wirtz, Petra H.</dc:contributor>
    <dcterms:title>Alpha-Adrenergic Mechanisms in the Cardiovascular Hyperreactivity to Norepinephrine-Infusion in Essential Hypertension</dcterms:title>
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    <dc:creator>von Känel, Roland</dc:creator>
    <dc:contributor>von Känel, Roland</dc:contributor>
    <dcterms:abstract xml:lang="eng">Aims: Essential hypertension (EHT) is characterized by cardiovascular hyperreactivity to stress but underlying mechanism are not fully understood. Here, we investigated the role of α-adrenergic receptors (α-AR) in the cardiovascular reactivity to a norepinephrine (NE)-stress reactivity-mimicking NE-infusion in essential hypertensive individuals (HT) as compared to normotensive individuals (NT).&lt;br /&gt;Methods: 24 male HT and 24 male NT participated in three experimental trials on three separate days with a 1-min infusion followed by a 15-min infusion. Trials varied in infusion-substances: placebo saline (Sal)-infusions (trial-1:Sal+Sal), NE-infusion without (trial-2:Sal+NE) or with non-selective α-AR blockade by phentolamine (PHE) (trial-3:PHE+NE). NE-infusion dosage (5µg/ml/min) and duration were chosen to mimic duration and physiological effects of NE-release in reaction to established stress induction protocols. We repeatedly measured systolic (SBP) and diastolic blood pressure (DBP) as well as heart rate before, during, and after infusions.&lt;br /&gt;Results: SBP and DBP reactivity to the three infusion-trials differed between HT and NT (p’s≤.014). HT exhibited greater BP reactivity to NE-infusion alone compared to NT (trial-2-vs-trial-1: p’s≤.033). Group differences in DBP reactivity to NE disappeared with prior PHE blockade (trial-3: p=.26), while SBP reactivity differences remained (trial-3: p=.016). Heart rate reactivity to infusion-trials did not differ between HT and NT (p=.73).&lt;br /&gt;Conclusion: Our findings suggest a mediating role of α-AR in DBP hyperreactivity to NE-infusion in EHT. However, in SBP hyperreactivity to NE-infusion in EHT, the functioning of α-AR seems impaired suggesting that the SBP hyperreactivity in hypertension is not mediated by α-AR.</dcterms:abstract>
    <dc:contributor>Heimgartner, Nadja</dc:contributor>
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    <dc:creator>Wirtz, Petra H.</dc:creator>
    <dc:creator>Stirnimann, Guido</dc:creator>
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