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PLGA particle vaccination elicits resident memory CD8 T cells protecting from tumors and infection

PLGA particle vaccination elicits resident memory CD8 T cells protecting from tumors and infection

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MACKERRACHER, Anna, Annette SOMMERSHOF, Marcus GROETTRUP, 2022. PLGA particle vaccination elicits resident memory CD8 T cells protecting from tumors and infection. In: European Journal of Pharmaceutical Sciences. Elsevier. 175, 106209. ISSN 0928-0987. eISSN 1879-0720. Available under: doi: 10.1016/j.ejps.2022.106209

@article{MacKerracher2022-08parti-57574, title={PLGA particle vaccination elicits resident memory CD8 T cells protecting from tumors and infection}, year={2022}, doi={10.1016/j.ejps.2022.106209}, volume={175}, issn={0928-0987}, journal={European Journal of Pharmaceutical Sciences}, author={MacKerracher, Anna and Sommershof, Annette and Groettrup, Marcus}, note={Article Number: 106209} }

Groettrup, Marcus Groettrup, Marcus 2022-05-19T05:25:35Z Sommershof, Annette 2022-05-19T05:25:35Z The essential role of tissue-resident memory T cells (T<sub>RM</sub> cells) in offering protection from recurring infections and malignant tumors is becoming increasingly clear. Due to their presence in many barrier tissues, T<sub>RM</sub> cells are ideally located to rapidly respond to re-encountered pathogens. Moreover, a host of studies has shown that the quantity of T<sub>RM</sub> cells correlates with increased survival rates in cancer patients. Therefore, vaccination strategies which induce a strong and sustained T<sub>RM</sub> cell response are particularly promising. In this study we show that this response can be induced by employing a prime-boost vaccination strategy using biodegradable poly (D,L-lactide-co-glycolide) microspheres (PLGA MS). A subcutaneous prime immunization followed by an intranasal boost immunization led to a strong T<sub>RM</sub> cell response in the lungs of mice 6 days after the boost vaccination. Although numbers subsequently declined, T<sub>RM</sub> cells were still detectable 60 days after vaccination. Functionally, we observed that immunized mice were protected from lung metastasis formation and tumor growth in a B16Bl6 melanoma model. Furthermore, the T<sub>RM</sub> cells induced by PLGA MS immunization provided protection in an infectious model using a recombinant influenza A virus (IAV). Taken together, these results show that the ability of PLGA MS to induce a strong T<sub>RM</sub> cell response further supports their use as a potent vaccine. eng MacKerracher, Anna Attribution-NonCommercial-NoDerivatives 4.0 International PLGA particle vaccination elicits resident memory CD8 T cells protecting from tumors and infection 2022-08 MacKerracher, Anna Sommershof, Annette

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