Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma

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BARRA, Lena, Jeroen S. DICKSCHAT, 2017. Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma. In: ChemBioChem. Wiley-VCH. 18(23), pp. 2358-2365. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201700462

@article{Barra2017Harzi-57553, title={Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma}, year={2017}, doi={10.1002/cbic.201700462}, number={23}, volume={18}, issn={1439-4227}, journal={ChemBioChem}, pages={2358--2365}, author={Barra, Lena and Dickschat, Jeroen S.} }

Harzianone Biosynthesis by the Biocontrol Fungus Trichoderma Analysis of the volatile terpenes produced by seven fungal strains of the genus Trichoderma by use of a closed-loop stripping apparatus (CLSA) revealed a common production of harzianone, a bioactive, structurally unique diterpenoid consisting of a fused tetracyclic 4,7,5,6-membered ring system. The terpene cyclization mechanism was studied by feeding experiments using selectively <sup>13</sup>C- and <sup>2</sup>H-labeled synthetic mevalonolactone isotopologues, followed by analysis of the incorporation patterns by <sup>13</sup>C NMR spectroscopy and GC/MS. The structure of harzianone was further supported from a <sup>13</sup>C,<sup>13</sup>C COSY experiment of the in-vivo-generated fully <sup>13</sup>C-labeled diterpene. Barra, Lena eng Dickschat, Jeroen S. 2022-05-17T09:17:18Z 2017 Barra, Lena Dickschat, Jeroen S. terms-of-use 2022-05-17T09:17:18Z

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