Pogostol biosynthesis by the endophytic fungus Geniculosporium

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BARRA, Lena, Barbara SCHULZ, Jeroen S. DICKSCHAT, 2014. Pogostol biosynthesis by the endophytic fungus Geniculosporium. In: ChemBioChem. Wiley-VCH. 15(16), pp. 2379-2383. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201402298

@article{Barra2014-11-03Pogos-57484, title={Pogostol biosynthesis by the endophytic fungus Geniculosporium}, year={2014}, doi={10.1002/cbic.201402298}, number={16}, volume={15}, issn={1439-4227}, journal={ChemBioChem}, pages={2379--2383}, author={Barra, Lena and Schulz, Barbara and Dickschat, Jeroen S.} }

terms-of-use eng Dickschat, Jeroen S. Dickschat, Jeroen S. Barra, Lena Six <sup>13</sup>C-labelled isotopomers of mevalonolactone were synthesised and used in feeding experiments with the endophytic fungus Geniculosporium. The high incorporation rates of <sup>13</sup>C-label into a sesquiterpene that was found in headspace extracts of the fungus enabled unambiguous identification of this volatile as pogostol without the need for compound purification, simply by collecting the volatile fraction with a closed-loop stripping apparatus followed by direct <sup>13</sup>C NMR analysis (CLSA-NMR). The feeding experiments also gave insights into the biosynthesis of pogostol, including stereochemical aspects of the terpene cyclisation reaction. The possible biological function of pogostol is discussed. Barra, Lena Schulz, Barbara 2022-05-10T09:55:49Z 2022-05-10T09:55:49Z Schulz, Barbara Pogostol biosynthesis by the endophytic fungus Geniculosporium 2014-11-03

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