p53-Mediated Tumor Suppression : DNA-Damage Response and Alternative Mechanisms

Pitolli, Consuelo; Wang, Ying; Candi, Eleonora; Shi, Yufang; Melino, Gerry; Amelio, Ivano

p53-Mediated Tumor Suppression : DNA-Damage Response and Alternative Mechanisms

Dateien

Pitolli_2-1uuvjsolnkug76.pdfGröße: 2.51 MBDownloads: 58

Datum

2019

Autor:innen

Pitolli, Consuelo

Wang, Ying

Candi, Eleonora

Shi, Yufang

Melino, Gerry

Amelio, Ivano

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Cancers. MDPI. 2019, 11(12), 1983. ISSN 2072-6694. eISSN 2072-6694. Available under: doi: 10.3390/cancers11121983

Zusammenfassung

The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the potentially crucial aspects related to its tumor suppressor activity.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

cell death; cancer; epigenetics; metabolism

Zitieren

ISO 690

PITOLLI, Consuelo, Ying WANG, Eleonora CANDI, Yufang SHI, Gerry MELINO, Ivano AMELIO, 2019. p53-Mediated Tumor Suppression : DNA-Damage Response and Alternative Mechanisms. In: Cancers. MDPI. 2019, 11(12), 1983. ISSN 2072-6694. eISSN 2072-6694. Available under: doi: 10.3390/cancers11121983

BibTex

@article{Pitolli2019p53Me-57164,
  year={2019},
  doi={10.3390/cancers11121983},
  title={p53-Mediated Tumor Suppression : DNA-Damage Response and Alternative Mechanisms},
  number={12},
  volume={11},
  issn={2072-6694},
  journal={Cancers},
  author={Pitolli, Consuelo and Wang, Ying and Candi, Eleonora and Shi, Yufang and Melino, Gerry and Amelio, Ivano},
  note={Article Number: 1983}
}

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