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Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors

Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors

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INSABATO, Luigi, Ivano AMELIO, Maria QUARTO, Antonella ZANNETTI, Fabio TOLINO, Gaia DE MAURO, Laura CERCHIA, Patrizia RICCIO, Daniel BAUMHOER, Gerolama CONDORELLI, 2009. Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors. In: Oncology. Karger. 77(6), pp. 378-384. ISSN 0030-2414. eISSN 1423-0232. Available under: doi: 10.1159/000276765

@article{Insabato2009Eleva-57135, title={Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors}, year={2009}, doi={10.1159/000276765}, number={6}, volume={77}, issn={0030-2414}, journal={Oncology}, pages={378--384}, author={Insabato, Luigi and Amelio, Ivano and Quarto, Maria and Zannetti, Antonella and Tolino, Fabio and de Mauro, Gaia and Cerchia, Laura and Riccio, Patrizia and Baumhoer, Daniel and Condorelli, Gerolama} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/57135"> <dc:creator>Amelio, Ivano</dc:creator> <dc:rights>terms-of-use</dc:rights> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:title>Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors</dcterms:title> <dc:contributor>Tolino, Fabio</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-04-01T08:01:55Z</dc:date> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Condorelli, Gerolama</dc:contributor> <dc:creator>de Mauro, Gaia</dc:creator> <dc:contributor>Riccio, Patrizia</dc:contributor> <dc:contributor>Amelio, Ivano</dc:contributor> <dc:contributor>Baumhoer, Daniel</dc:contributor> <dc:contributor>Quarto, Maria</dc:contributor> <dc:creator>Zannetti, Antonella</dc:creator> <dc:creator>Riccio, Patrizia</dc:creator> <dc:creator>Tolino, Fabio</dc:creator> <dc:contributor>de Mauro, Gaia</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Condorelli, Gerolama</dc:creator> <dc:contributor>Zannetti, Antonella</dc:contributor> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:language>eng</dc:language> <dc:contributor>Cerchia, Laura</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract xml:lang="eng">Objectives: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. Methods: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. Results: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. Conclusions: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors.</dcterms:abstract> <dc:creator>Insabato, Luigi</dc:creator> <dc:creator>Cerchia, Laura</dc:creator> <dc:creator>Quarto, Maria</dc:creator> <dc:contributor>Insabato, Luigi</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-04-01T08:01:55Z</dcterms:available> <dc:creator>Baumhoer, Daniel</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57135"/> <dcterms:issued>2009</dcterms:issued> </rdf:Description> </rdf:RDF>

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