@article{Insabato2009Eleva-57135,
  year={2009},
  doi={10.1159/000276765},
  title={Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors},
  number={6},
  volume={77},
  issn={0030-2414},
  journal={Oncology},
  pages={378--384},
  author={Insabato, Luigi and Amelio, Ivano and Quarto, Maria and Zannetti, Antonella and Tolino, Fabio and de Mauro, Gaia and Cerchia, Laura and Riccio, Patrizia and Baumhoer, Daniel and Condorelli, Gerolama}
}

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    <dc:contributor>Condorelli, Gerolama</dc:contributor>
    <dcterms:title>Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors</dcterms:title>
    <dc:contributor>Amelio, Ivano</dc:contributor>
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    <dc:contributor>Baumhoer, Daniel</dc:contributor>
    <dc:contributor>de Mauro, Gaia</dc:contributor>
    <dc:contributor>Tolino, Fabio</dc:contributor>
    <dc:contributor>Riccio, Patrizia</dc:contributor>
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    <dc:language>eng</dc:language>
    <dcterms:abstract xml:lang="eng">Objectives: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. Methods: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. Results: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. Conclusions: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors.</dcterms:abstract>
    <dcterms:issued>2009</dcterms:issued>
    <dc:creator>Quarto, Maria</dc:creator>
    <dc:creator>Zannetti, Antonella</dc:creator>
    <dc:creator>Cerchia, Laura</dc:creator>
    <dc:contributor>Zannetti, Antonella</dc:contributor>
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    <dc:contributor>Quarto, Maria</dc:contributor>
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    <dc:creator>Baumhoer, Daniel</dc:creator>
    <dc:creator>Condorelli, Gerolama</dc:creator>
    <dc:creator>Riccio, Patrizia</dc:creator>
    <dc:creator>Insabato, Luigi</dc:creator>
    <dc:creator>Amelio, Ivano</dc:creator>
    <dc:contributor>Insabato, Luigi</dc:contributor>
    <dc:creator>Tolino, Fabio</dc:creator>
    <dc:creator>de Mauro, Gaia</dc:creator>
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