p53MutaGene : an online tool to estimate the effect of p53 mutational status on gene regulation in cancer
| Type of Publication: | Journal article |
| Publication status: | Published |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-2-9yh61ke271le1 |
| Author: | Amelio, Ivano; Knight, Richard A.; Lisitsa, Andrey; Melino, Gerry; Antonov, Alexey V. |
| Year of publication: | 2016 |
| Published in: | Cell death & disease ; 7 (2016). - e2148. - Nature Publishing Group. - eISSN 2041-4889 |
| Pubmed ID: | 26986515 |
| DOI (citable link): | https://dx.doi.org/10.1038/cddis.2016.42 |
| Summary: |
p53MutaGene is the first online tool for statistical validation of hypotheses regarding the effect of p53 mutational status on gene regulation in cancer. This tool is based on several large-scale clinical gene expression data sets and currently covers breast, colon and lung cancers. The tool detects differential co-expression patterns in expression data between p53 mutated versus p53 normal samples for the user-specified genes. Statistically significant differential co-expression for a gene pair is indicative that regulation of two genes is sensitive to the presence of p53 mutations. p53MutaGene can be used in 'single mode' where the user can test a specific pair of genes or in 'discovery mode' designed for analysis of several genes. Using several examples, we demonstrate that p53MutaGene is a useful tool for fast statistical validation in clinical data of p53-dependent gene regulation patterns. The tool is freely available at http://www.bioprofiling.de/tp53.
|
| Subject (DDC): | 570 Biosciences, Biology |
| Link to License: | In Copyright |
| Refereed: | Yes |
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AMELIO, Ivano, Richard A. KNIGHT, Andrey LISITSA, Gerry MELINO, Alexey V. ANTONOV, 2016. p53MutaGene : an online tool to estimate the effect of p53 mutational status on gene regulation in cancer. In: Cell death & disease. Nature Publishing Group. 7, e2148. eISSN 2041-4889. Available under: doi: 10.1038/cddis.2016.42
@article{Amelio2016-03-17p53Mu-57117, title={p53MutaGene : an online tool to estimate the effect of p53 mutational status on gene regulation in cancer}, year={2016}, doi={10.1038/cddis.2016.42}, volume={7}, journal={Cell death & disease}, author={Amelio, Ivano and Knight, Richard A. and Lisitsa, Andrey and Melino, Gerry and Antonov, Alexey V.}, note={Article Number: e2148} }
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