p53MutaGene : an online tool to estimate the effect of p53 mutational status on gene regulation in cancer
| Type of Publication: | Journal article |
| Publication status: | Published |
| URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-2-9yh61ke271le1 |
| Author: | Amelio, Ivano; Knight, Richard A.; Lisitsa, Andrey; Melino, Gerry; Antonov, Alexey V. |
| Year of publication: | 2016 |
| Published in: | Cell death & disease ; 7 (2016). - e2148. - Nature Publishing Group. - eISSN 2041-4889 |
| Pubmed ID: | 26986515 |
| DOI (citable link): | https://dx.doi.org/10.1038/cddis.2016.42 |
| Summary: |
p53MutaGene is the first online tool for statistical validation of hypotheses regarding the effect of p53 mutational status on gene regulation in cancer. This tool is based on several large-scale clinical gene expression data sets and currently covers breast, colon and lung cancers. The tool detects differential co-expression patterns in expression data between p53 mutated versus p53 normal samples for the user-specified genes. Statistically significant differential co-expression for a gene pair is indicative that regulation of two genes is sensitive to the presence of p53 mutations. p53MutaGene can be used in 'single mode' where the user can test a specific pair of genes or in 'discovery mode' designed for analysis of several genes. Using several examples, we demonstrate that p53MutaGene is a useful tool for fast statistical validation in clinical data of p53-dependent gene regulation patterns. The tool is freely available at http://www.bioprofiling.de/tp53.
|
| Subject (DDC): | 570 Biosciences, Biology |
| Link to License: | In Copyright |
| Refereed: | Yes |
Cite This
Files in this item
![[PDF]](/themes/Kops/images/mimes/pdf.png "PDF file"){kind=small}
AMELIO, Ivano, Richard A. KNIGHT, Andrey LISITSA, Gerry MELINO, Alexey V. ANTONOV, 2016. p53MutaGene : an online tool to estimate the effect of p53 mutational status on gene regulation in cancer. In: Cell death & disease. Nature Publishing Group. 7, e2148. eISSN 2041-4889. Available under: doi: 10.1038/cddis.2016.42
@article{Amelio2016-03-17p53Mu-57117, title={p53MutaGene : an online tool to estimate the effect of p53 mutational status on gene regulation in cancer}, year={2016}, doi={10.1038/cddis.2016.42}, volume={7}, journal={Cell death & disease}, author={Amelio, Ivano and Knight, Richard A. and Lisitsa, Andrey and Melino, Gerry and Antonov, Alexey V.}, note={Article Number: e2148} }
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/57117"> <dc:contributor>Lisitsa, Andrey</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Lisitsa, Andrey</dc:creator> <dcterms:abstract xml:lang="eng">p53MutaGene is the first online tool for statistical validation of hypotheses regarding the effect of p53 mutational status on gene regulation in cancer. This tool is based on several large-scale clinical gene expression data sets and currently covers breast, colon and lung cancers. The tool detects differential co-expression patterns in expression data between p53 mutated versus p53 normal samples for the user-specified genes. Statistically significant differential co-expression for a gene pair is indicative that regulation of two genes is sensitive to the presence of p53 mutations. p53MutaGene can be used in 'single mode' where the user can test a specific pair of genes or in 'discovery mode' designed for analysis of several genes. Using several examples, we demonstrate that p53MutaGene is a useful tool for fast statistical validation in clinical data of p53-dependent gene regulation patterns. The tool is freely available at http://www.bioprofiling.de/tp53.</dcterms:abstract> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Knight, Richard A.</dc:contributor> <dc:creator>Antonov, Alexey V.</dc:creator> <dc:rights>terms-of-use</dc:rights> <dc:creator>Amelio, Ivano</dc:creator> <dcterms:title>p53MutaGene : an online tool to estimate the effect of p53 mutational status on gene regulation in cancer</dcterms:title> <dc:creator>Melino, Gerry</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-31T12:41:14Z</dc:date> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57117"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57117/3/Amelio_2-9yh61ke271le1.pdf"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-31T12:41:14Z</dcterms:available> <dcterms:issued>2016-03-17</dcterms:issued> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57117/3/Amelio_2-9yh61ke271le1.pdf"/> <dc:contributor>Melino, Gerry</dc:contributor> <dc:contributor>Antonov, Alexey V.</dc:contributor> <dc:creator>Knight, Richard A.</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Amelio, Ivano</dc:contributor> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>
Downloads since Mar 31, 2022 (Information about access statistics)
| Amelio_2-9yh61ke271le1.pdf | 17 |
This item appears in the following Collection(s)
Search KOPS
Browse
My Account
