Tissue-specific expression of p73 C-terminal isoforms in mice

Cite This

Files in this item

Checksum: MD5:ae5c9378f7a3cf185043d771f1026fc7

GRESPI, Francesca, Ivano AMELIO, Paola TUCCI, Margherita ANNICCHIARICO-PETRUZZELLI, Gerry MELINO, 2012. Tissue-specific expression of p73 C-terminal isoforms in mice. In: Cell cycle. Taylor & Francis. 11(23), pp. 4474-4483. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.4161/cc.22787

@article{Grespi2012-12-01Tissu-57107, title={Tissue-specific expression of p73 C-terminal isoforms in mice}, year={2012}, doi={10.4161/cc.22787}, number={23}, volume={11}, issn={1538-4101}, journal={Cell cycle}, pages={4474--4483}, author={Grespi, Francesca and Amelio, Ivano and Tucci, Paola and Annicchiarico-Petruzzelli, Margherita and Melino, Gerry} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/57107"> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:title>Tissue-specific expression of p73 C-terminal isoforms in mice</dcterms:title> <dc:creator>Amelio, Ivano</dc:creator> <dc:contributor>Melino, Gerry</dc:contributor> <dc:contributor>Annicchiarico-Petruzzelli, Margherita</dc:contributor> <dc:contributor>Grespi, Francesca</dc:contributor> <dc:creator>Annicchiarico-Petruzzelli, Margherita</dc:creator> <dc:creator>Tucci, Paola</dc:creator> <dc:language>eng</dc:language> <dc:creator>Melino, Gerry</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Grespi, Francesca</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57107"/> <dcterms:abstract xml:lang="eng">p73 is a p53 family transcription factor. Due to the presence in the 5' flanking region of two promoters, there are two N-terminal variants, TAp73, which retains a fully active transactivation domain (TA), and ΔNp73, in which the N terminus is truncated. In addition, extensive 3' splicing gives rise to at least seven distinctive isoforms; TAp73-selective knockout highlights its role as a regulator of cell death, senescence and tumor suppressor. ΔNp73-selective knockout, on the other hand, highlights anti-apoptotic function of ΔNp73 and its involvement in DNA damage response. In this work, we investigated the expression pattern of murine p73 C-terminal isoforms. By using a RT-PCR approach, we were able to detect mRNAs of all the C-terminal isoforms described in humans. We characterized their in vivo expression profile in mouse organs and in different mouse developmental stages. Finally, we investigated p73 C-terminal expression profile following DNA damage, ex vivo after primary cultures treatment and in vivo after systemic administration of cytotoxic compounds. Overall, our study first elucidates spatio-temporal expression of mouse p73 isoforms and provides novel insights on their expression-switch under triggered conditions.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-31T06:09:29Z</dc:date> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-31T06:09:29Z</dcterms:available> <dcterms:issued>2012-12-01</dcterms:issued> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Amelio, Ivano</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57107/1/Grespi_2-sipcfjf858tq4.pdf"/> <dc:contributor>Tucci, Paola</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57107/1/Grespi_2-sipcfjf858tq4.pdf"/> <dc:rights>terms-of-use</dc:rights> </rdf:Description> </rdf:RDF>

Downloads since Mar 31, 2022 (Information about access statistics)

Grespi_2-sipcfjf858tq4.pdf 10

This item appears in the following Collection(s)

Search KOPS


Browse

My Account