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Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer

Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer

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SICA, Giuseppe S., Cristina FIORANI, Carmine STOLFI, Giovanni MONTELEONE, Eleonora CANDI, Ivano AMELIO, Valeria CATANI, Simone SIBIO, Andrea DIVIZIA, Giorgia TEMA, Edoardo IACULLI, Achille L. GASPARI, 2015. Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer. In: Oncotarget. Impact Journals LLC. 6(15), pp. 13402-13415. eISSN 1949-2553. Available under: doi: 10.18632/oncotarget.2830

@article{Sica2015Perit-57076, title={Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer}, year={2015}, doi={10.18632/oncotarget.2830}, number={15}, volume={6}, journal={Oncotarget}, pages={13402--13415}, author={Sica, Giuseppe S. and Fiorani, Cristina and Stolfi, Carmine and Monteleone, Giovanni and Candi, Eleonora and Amelio, Ivano and Catani, Valeria and Sibio, Simone and Divizia, Andrea and Tema, Giorgia and Iaculli, Edoardo and Gaspari, Achille L.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/57076"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-30T08:59:37Z</dc:date> <dc:creator>Tema, Giorgia</dc:creator> <dc:creator>Gaspari, Achille L.</dc:creator> <dc:creator>Catani, Valeria</dc:creator> <dcterms:issued>2015</dcterms:issued> <dc:contributor>Candi, Eleonora</dc:contributor> <dc:contributor>Stolfi, Carmine</dc:contributor> <dc:contributor>Monteleone, Giovanni</dc:contributor> <dc:creator>Divizia, Andrea</dc:creator> <dc:creator>Monteleone, Giovanni</dc:creator> <dc:contributor>Gaspari, Achille L.</dc:contributor> <dcterms:title>Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Catani, Valeria</dc:contributor> <dc:creator>Stolfi, Carmine</dc:creator> <dc:creator>Iaculli, Edoardo</dc:creator> <dc:contributor>Amelio, Ivano</dc:contributor> <dc:contributor>Fiorani, Cristina</dc:contributor> <dc:contributor>Tema, Giorgia</dc:contributor> <dc:contributor>Sica, Giuseppe S.</dc:contributor> <dc:creator>Sibio, Simone</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57076"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Fiorani, Cristina</dc:creator> <dc:contributor>Sibio, Simone</dc:contributor> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Iaculli, Edoardo</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57076/1/Sica_2-v6f6dzvvsqnh9.pdf"/> <dc:language>eng</dc:language> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-30T08:59:37Z</dcterms:available> <dc:creator>Sica, Giuseppe S.</dc:creator> <dc:contributor>Divizia, Andrea</dc:contributor> <dc:creator>Candi, Eleonora</dc:creator> <dc:creator>Amelio, Ivano</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">Recurrence of colorectal cancer (CRC) following a potentially curative resection is a challenging clinical problem. Matrix metalloproteinase-7 (MMP-7) is over-expressed by CRC cells and supposed to play a major role in CRC cell diffusion and metastasis. MMP-7 RNA expression was assessed by real-time PCR using specific primers in peritoneal washing fluid obtained during surgical procedure. After surgery, patients underwent a regular follow up for assessing recurrence. transcripts for MMP-7 were detected in 31/57 samples (54%). Patients were followed-up (range 20-48 months) for recurrence prevention. Recurrence was diagnosed in 6 out of 55 patients (11%) and two patients eventually died because of this. Notably, all the six patients who had relapsed were positive for MMP-7. Sensitivity and specificity of the test were 100% and 49% respectively. Data from patients have also been corroborated by computational approaches. Public available coloncarcinoma datasets have been employed to confirm MMP7 clinical impact on the disease. Interestingly, MMP-7 expression appeared correlated to Tgfb-1, and correlation of the two factors represented a poor prognostic factor. This study proposes positivity of MMP-7 in peritoneal cavity as a novel biomarker for predicting disease recurrence in patients with CRC.</dcterms:abstract> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57076/1/Sica_2-v6f6dzvvsqnh9.pdf"/> </rdf:Description> </rdf:RDF>

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