TAp73 transcriptionally represses BNIP3 expression

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PETROVA, Varvara, Mara MANCINI, Massimiliano AGOSTINI, Richard A. KNIGHT, Margherita ANNICCHIARICO-PETRUZZELLI, Nikolai A. BARLEV, Gerry MELINO, Ivano AMELIO, 2015. TAp73 transcriptionally represses BNIP3 expression. In: Cell cycle. Taylor & Francis. 14(15), pp. 2484-2493. ISSN 1538-4101. eISSN 1551-4005. Available under: doi: 10.1080/15384101.2015.1044178

@article{Petrova2015-08-03TAp73-57074, title={TAp73 transcriptionally represses BNIP3 expression}, year={2015}, doi={10.1080/15384101.2015.1044178}, number={15}, volume={14}, issn={1538-4101}, journal={Cell cycle}, pages={2484--2493}, author={Petrova, Varvara and Mancini, Mara and Agostini, Massimiliano and Knight, Richard A. and Annicchiarico-Petruzzelli, Margherita and Barlev, Nikolai A. and Melino, Gerry and Amelio, Ivano} }

Barlev, Nikolai A. Barlev, Nikolai A. 2015-08-03 2022-03-30T08:52:46Z Mancini, Mara TAp73 transcriptionally represses BNIP3 expression Mancini, Mara Annicchiarico-Petruzzelli, Margherita 2022-03-30T08:52:46Z Knight, Richard A. Agostini, Massimiliano Melino, Gerry Petrova, Varvara Amelio, Ivano Agostini, Massimiliano eng Petrova, Varvara Amelio, Ivano Knight, Richard A. Annicchiarico-Petruzzelli, Margherita Melino, Gerry terms-of-use TAp73 is a tumor suppressor transcriptional factor, belonging to p53 family. Alteration of TAp73 in tumors might lead to reduced DNA damage response, cell cycle arrest and apoptosis. Carcinogen-induced TAp73<sup>-/-</sup> tumors display also increased angiogenesis, associated to hyperactivition of hypoxia inducible factor signaling. Here, we show that TAp73 suppresses BNIP3 expression, directly binding its gene promoter. BNIP3 is a hypoxia responsive protein, involved in a variety of cellular processes, such as autophagy, mitophagy, apoptosis and necrotic-like cell death. Therefore, through different cellular process altered expression of BNIP3 may differently contribute to cancer development and progression. We found a significant upregulation of BNIP3 in human lung cancer datasets, and we identified a direct association between BNIP3 expression and survival rate of lung cancer patients. Our data therefore provide a novel transcriptional target of TAp73, associated to its antagonistic role on HIF signaling in cancer, which might play a role in tumor suppression.

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