Type of Publication: | Journal article |
Publication status: | Published |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1q8r3mtxl0v832 |
Author: | Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Kroemer, Guido et al. |
Year of publication: | 2018 |
Published in: | Cell death and differentiation ; 25 (2018), 3. - pp. 486-541. - Nature Publishing Group. - ISSN 1350-9047. - eISSN 1476-5403 |
Pubmed ID: | 29362479 |
DOI (citable link): | https://dx.doi.org/10.1038/s41418-017-0012-4 |
Summary: |
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
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Subject (DDC): | 570 Biosciences, Biology |
Link to License: | Attribution-NonCommercial-ShareAlike 4.0 International |
Refereed: | Yes |
GALLUZZI, Lorenzo, Ilio VITALE, Stuart A. AARONSON, John M. ABRAMS, Dieter ADAM, Patrizia AGOSTINIS, Emad S. ALNEMRI, Lucia ALTUCCI, Ivano AMELIO, Guido KROEMER, 2018. Molecular mechanisms of cell death : recommendations of the Nomenclature Committee on Cell Death 2018. In: Cell death and differentiation. Nature Publishing Group. 25(3), pp. 486-541. ISSN 1350-9047. eISSN 1476-5403. Available under: doi: 10.1038/s41418-017-0012-4
@article{Galluzzi2018Molec-57065, title={Molecular mechanisms of cell death : recommendations of the Nomenclature Committee on Cell Death 2018}, year={2018}, doi={10.1038/s41418-017-0012-4}, number={3}, volume={25}, issn={1350-9047}, journal={Cell death and differentiation}, pages={486--541}, author={Galluzzi, Lorenzo and Vitale, Ilio and Aaronson, Stuart A. and Abrams, John M. and Adam, Dieter and Agostinis, Patrizia and Alnemri, Emad S. and Altucci, Lucia and Amelio, Ivano and Kroemer, Guido} }
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