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Correlations of Hippocampal Atrophy and Focal Low-Frequency Magnetic Activity in Alzheimer Disease : Volumetric MR Imaging-Magnetoencephalographic Study

Correlations of Hippocampal Atrophy and Focal Low-Frequency Magnetic Activity in Alzheimer Disease : Volumetric MR Imaging-Magnetoencephalographic Study

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FERNÁNDEZ, Alberto, Juan ARRAZOLA, Fernando MAESTÚ, Carlos AMO, Pedro GIL-GREGORIO, Christian WIENBRUCH, Tomás ORTIZ, 2003. Correlations of Hippocampal Atrophy and Focal Low-Frequency Magnetic Activity in Alzheimer Disease : Volumetric MR Imaging-Magnetoencephalographic Study. In: American Journal of Neuroradiology : AJNR. American Society of Neuroradiology. 24(3), pp. 481-487. ISSN 0195-6108. eISSN 1936-959X

@article{Fernandez2003Corre-56617, title={Correlations of Hippocampal Atrophy and Focal Low-Frequency Magnetic Activity in Alzheimer Disease : Volumetric MR Imaging-Magnetoencephalographic Study}, url={http://www.ajnr.org/content/24/3/481.long}, year={2003}, number={3}, volume={24}, issn={0195-6108}, journal={American Journal of Neuroradiology : AJNR}, pages={481--487}, author={Fernández, Alberto and Arrazola, Juan and Maestú, Fernando and Amo, Carlos and Gil-Gregorio, Pedro and Wienbruch, Christian and Ortiz, Tomás} }

Ortiz, Tomás Amo, Carlos Amo, Carlos 2022-02-21T14:21:45Z Correlations of Hippocampal Atrophy and Focal Low-Frequency Magnetic Activity in Alzheimer Disease : Volumetric MR Imaging-Magnetoencephalographic Study eng 2003 Maestú, Fernando Fernández, Alberto Gil-Gregorio, Pedro Gil-Gregorio, Pedro BACKGROUND AND PURPOSE: Patients with Alzheimer disease (AD) have more low-frequency activity on conventional EEG and increased focal magnetoencephalographic (MEG) dipole density (DD) in delta and theta bands. This activity concurs with atrophy and reduced metabolic and perfusion rates, particularly in temporoparietal structures. The relationship between functional and structural measures and their conjoined capability to improve the diagnosis of AD were assessed in this study.<br /><br />METHODS: Whole-head MEG recordings were obtained in 15 patients in whom the diagnosis of AD had been made and in 16 healthy control subjects during a resting condition. MR imaging volumetric data were also obtained; these included global cerebral, temporal lobe, and hippocampal volumes.<br /><br />RESULTS: DD in the delta and theta bands was enhanced in the AD group compared with the healthy control subjects. Slow-wave activity differed significantly between the groups in the temporoparietal regions of both hemispheres. Left hippocampal volume was correlated with left temporal and parietal delta DD and left temporal theta DD. A combination of left hippocampal volume and left temporal theta DD enabled correct classification in 87.1% of the patients with AD or control subjects.<br /><br />CONCLUSION: Results support the predominant role of temporoparietal hypofunction as defined by DD and hippocampal structural deficits shown on MR images in patients with AD. A multidisciplinary perspective of different techniques may improve our understanding of the disease and our diagnostic abilities. Wienbruch, Christian 2022-02-21T14:21:45Z terms-of-use Ortiz, Tomás Wienbruch, Christian Arrazola, Juan Arrazola, Juan Maestú, Fernando Fernández, Alberto

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