Do Mutations Turn p53 into an Oncogene?

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PITOLLI, Consuelo, Ying WANG, Mara MANCINI, Yufang SHI, Gerry MELINO, Ivano AMELIO, 2019. Do Mutations Turn p53 into an Oncogene?. In: International Journal of Molecular Sciences. MDPI. 20(24), 6241. ISSN 1661-6596. eISSN 1422-0067. Available under: doi: 10.3390/ijms20246241

@article{Pitolli2019-12-11Mutat-56607, title={Do Mutations Turn p53 into an Oncogene?}, year={2019}, doi={10.3390/ijms20246241}, number={24}, volume={20}, issn={1661-6596}, journal={International Journal of Molecular Sciences}, author={Pitolli, Consuelo and Wang, Ying and Mancini, Mara and Shi, Yufang and Melino, Gerry and Amelio, Ivano}, note={Article Number: 6241} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Wang, Ying</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Mancini, Mara</dc:contributor> <dspace:isPartOfCollection rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:contributor>Wang, Ying</dc:contributor> <dc:contributor>Amelio, Ivano</dc:contributor> <dcterms:hasPart rdf:resource=""/> <dcterms:abstract xml:lang="eng">The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.</dcterms:abstract> <dc:creator>Mancini, Mara</dc:creator> <dc:creator>Pitolli, Consuelo</dc:creator> <dcterms:issued>2019-12-11</dcterms:issued> <dc:contributor>Melino, Gerry</dc:contributor> <dcterms:isPartOf rdf:resource=""/> <dcterms:title>Do Mutations Turn p53 into an Oncogene?</dcterms:title> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Pitolli, Consuelo</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Shi, Yufang</dc:creator> <dc:creator>Amelio, Ivano</dc:creator> <dcterms:available rdf:datatype="">2022-02-21T12:37:31Z</dcterms:available> <dspace:hasBitstream rdf:resource=""/> <dc:contributor>Shi, Yufang</dc:contributor> <dcterms:rights rdf:resource=""/> <dc:creator>Melino, Gerry</dc:creator> <dc:date rdf:datatype="">2022-02-21T12:37:31Z</dc:date> <dc:rights>Attribution 4.0 International</dc:rights> </rdf:Description> </rdf:RDF>

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