KOPS - The Institutional Repository of the University of Konstanz

Identification of JAK/STAT pathway Regulators : Insights from RNAi screens

Identification of JAK/STAT pathway Regulators : Insights from RNAi screens

Cite This

Files in this item

Checksum: MD5:7a7a68d3641863cf894e2184083d7de6

MÜLLER, Patrick, Michael BOUTROS, Martin P. ZEIDLER, 2008. Identification of JAK/STAT pathway Regulators : Insights from RNAi screens. In: Seminars in Cell & Developmental Biology. Elsevier. 19(4), pp. 360-369. ISSN 1084-9521. eISSN 1096-3634. Available under: doi: 10.1016/j.semcdb.2008.06.001

@article{Muller2008-08Ident-56530, title={Identification of JAK/STAT pathway Regulators : Insights from RNAi screens}, year={2008}, doi={10.1016/j.semcdb.2008.06.001}, number={4}, volume={19}, issn={1084-9521}, journal={Seminars in Cell & Developmental Biology}, pages={360--369}, author={Müller, Patrick and Boutros, Michael and Zeidler, Martin P.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/56530"> <dc:creator>Boutros, Michael</dc:creator> <dc:creator>Müller, Patrick</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:issued>2008-08</dcterms:issued> <dc:contributor>Zeidler, Martin P.</dc:contributor> <dc:contributor>Boutros, Michael</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56530/1/Mueller_2-1nuo8gly0pjlt7.pdf"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/3.0/"/> <dc:language>eng</dc:language> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/56530/1/Mueller_2-1nuo8gly0pjlt7.pdf"/> <dcterms:title>Identification of JAK/STAT pathway Regulators : Insights from RNAi screens</dcterms:title> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56530"/> <dc:contributor>Müller, Patrick</dc:contributor> <dc:creator>Zeidler, Martin P.</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-11T09:23:31Z</dc:date> <dc:rights>Attribution-NonCommercial-NoDerivs 3.0 Unported</dc:rights> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract xml:lang="eng">While many core JAK/STAT pathway components have been discovered in Drosophila via classical genetic approaches, the identification of pathway regulators has been more challenging. Recently two cell-based RNAi screens for JAK/STAT pathway regulators have been undertaken using libraries of double-stranded RNAs targeting a large proportion of the predicted Drosophila transcriptome. While both screens identified multiple regulators, only relatively few loci are common to both data sets. Here we compare the two screens and discuss these differences. Although many factors are likely to be contributory, differences in the assay design are of key importance. Low levels of stimulation favouring the identification of negative pathway regulators and high levels of stimulation favouring the identification of positively acting factors. Ultimately, the results from both screens are likely to be largely complementary and have identified a range of novel candidate regulators of JAK/STAT pathway activity as a starting point for new research directions in the future.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-11T09:23:31Z</dcterms:available> </rdf:Description> </rdf:RDF>

Downloads since Feb 11, 2022 (Information about access statistics)

Mueller_2-1nuo8gly0pjlt7.pdf 42

This item appears in the following Collection(s)

Attribution-NonCommercial-NoDerivs 3.0 Unported Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Unported

Search KOPS


Browse

My Account