Hypoxia as a physiological cue and pathological stress for coral larvae

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ALDERDICE, Rachel, Mathieu PERNICE, Anny CARDENAS, David J HUGHES, Peter L HARRISON, Nadine BOULOTTE, Katie CHARTRAND, Michael KÜHL, David J SUGGETT, Christian R. VOOLSTRA, 2022. Hypoxia as a physiological cue and pathological stress for coral larvae. In: Molecular Ecology. Wiley. 31(2), pp. 571-587. ISSN 0962-1083. eISSN 1365-294X. Available under: doi: 10.1111/mec.16259

@article{Alderdice2022-01Hypox-55650, title={Hypoxia as a physiological cue and pathological stress for coral larvae}, year={2022}, doi={10.1111/mec.16259}, number={2}, volume={31}, issn={0962-1083}, journal={Molecular Ecology}, pages={571--587}, author={Alderdice, Rachel and Pernice, Mathieu and Cardenas, Anny and Hughes, David J and Harrison, Peter L and Boulotte, Nadine and Chartrand, Katie and Kühl, Michael and Suggett, David J and Voolstra, Christian R.} }

Boulotte, Nadine 2022-01 2021-11-25T11:53:08Z Ocean deoxygenation events are intensifying worldwide and can rapidly drive adult corals into a state of metabolic crisis and bleaching-induced mortality, but whether coral larvae are subject to similar stress remains untested. We experimentally exposed apo-symbiotic coral larvae of Acropora selago to deoxygenation stress with subsequent reoxygenation aligned to their night-day light cycle, and followed their gene expression using RNA-Seq. After 12 h of deoxygenation stress (~2 mg O<sub>2</sub> /L), coral planulae demonstrated a low expression of HIF-targeted hypoxia response genes concomitant with a significantly high expression of PHD2 (a promoter of HIFα proteasomal degradation), similar to corresponding adult corals. Despite exhibiting a consistent swimming phenotype compared to control samples, the differential gene expression observed in planulae exposed to deoxygenation-reoxygenation suggests a disruption of pathways involved in developmental regulation, mitochondrial activity, lipid metabolism, and O<sub>2</sub> -sensitive epigenetic regulators. Importantly, we found that treated larvae exhibited a disruption in the expression of conserved HIF-targeted developmental regulators, for example, Homeobox (HOX) genes, corroborating how changes in external oxygen levels can affect animal development. We discuss how the observed deoxygenation responses may be indicative of a possible acclimation response or alternatively may imply negative latent impacts for coral larval fitness. Pernice, Mathieu Kühl, Michael Chartrand, Katie Alderdice, Rachel Alderdice, Rachel Attribution-NonCommercial 4.0 International Cardenas, Anny Cardenas, Anny Hughes, David J Harrison, Peter L eng Boulotte, Nadine Pernice, Mathieu Hughes, David J Harrison, Peter L Voolstra, Christian R. Suggett, David J Suggett, David J Chartrand, Katie 2021-11-25T11:53:08Z Hypoxia as a physiological cue and pathological stress for coral larvae Kühl, Michael Voolstra, Christian R.

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