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A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals

A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals

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MISIAK, Błażej, Marita PRUESSNER, Jerzy SAMOCHOWIEC, Michał WIŚNIEWSKI, Artur REGINIA, Bartłomiej STAŃCZYKIEWICZ, 2021. A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals. In: Frontiers in Neuroendocrinology. Elsevier. 62, 100930. ISSN 0091-3022. eISSN 1095-6808. Available under: doi: 10.1016/j.yfrne.2021.100930

@article{Misiak2021metaa-55410, title={A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals}, year={2021}, doi={10.1016/j.yfrne.2021.100930}, volume={62}, issn={0091-3022}, journal={Frontiers in Neuroendocrinology}, author={Misiak, Błażej and Pruessner, Marita and Samochowiec, Jerzy and Wiśniewski, Michał and Reginia, Artur and Stańczykiewicz, Bartłomiej}, note={Article Number: 100930} }

Pruessner, Marita Reginia, Artur Reginia, Artur Wiśniewski, Michał Wiśniewski, Michał Samochowiec, Jerzy Pruessner, Marita 2021 A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals Misiak, Błażej Stańczykiewicz, Bartłomiej 2021-10-29T07:48:15Z Misiak, Błażej Stańczykiewicz, Bartłomiej Dysregulated cortisol responses and glucose metabolism have been reported in psychosis. We performed a random-effects meta-analysis of cortisol responses in first-episode psychosis (FEP) and psychosis risk states, taking into consideration glucose metabolism. A total of 47 studies were included. Unstimulated blood cortisol levels were significantly higher (g = 0.48, 95 %CI: 0.25–0.70, p < 0.001) in FEP, but not in psychosis risk states (g = 0.39, 95 %CI: −0.42–1.21, p = 0.342), compared to controls. Cortisol awakening response (CAR) was attenuated in FEP (g = −0.40, 95 %CI: −0.68 - −0.12, p = 0.006), but not in psychosis risk states (p = 0.433). Glucose and insulin levels were positively correlated with unstimulated blood cortisol levels in FEP. Our meta-analysis supports previous findings of elevated blood cortisol levels and attenuated CAR in FEP. Future research should focus on identifying the common denominators for alterations in stress hormones and glucose metabolism. 2021-10-29T07:48:15Z eng Attribution 4.0 International Samochowiec, Jerzy

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