DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers

The aftermath of traumatization lives on in the neural and epigenetic traces creating a momentum of affliction in the psychological and social realm. Can psychotherapy reorganise these memories through changes in DNA methylation signatures? Using a randomised controlled parallel group design, we examined methylome-wide changes in saliva samples of 84 female former child soldiers from Eastern DR Congo before and six months after Narrative Exposure Therapy. Treatment predicted differentially methylated positions (DMPs) related to ALCAM, RIPOR2, AFAP1 and MOCOS. In addition, treatment associations overlapped at gene level with baseline clinical and social outcomes. Treatment related DMPs are involved in memory formation—the key agent in trauma focused treatments—and enriched for molecular pathways commonly affected by trauma related disorders. Results were partially replicated in an independent sample of 53 female former child soldiers from Northern Uganda. Our results suggest a molecular impact of psychological treatment in women with war-related childhood trauma.

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CARLEIAL, Samuel, Daniel NÄTT, Eva UNTERNAEHRER, Thomas ELBERT, Katy ROBJANT, Sarah WILKER, Vanja VUKOJEVIC, Iris-Tatjana KOLASSA, Anja C. RUKUNDO-ZELLER, Anke KOEBACH, 2021. DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers. In: Scientific Reports. Springer Nature. 2021, 11, 18493. eISSN 2045-2322. Available under: doi: 10.1038/s41598-021-98067-9

BibTex

@article{Carleial2021-09-16methy-55191,
  year={2021},
  doi={10.1038/s41598-021-98067-9},
  title={DNA methylation changes following narrative exposure therapy in a randomized controlled trial with female former child soldiers},
  volume={11},
  journal={Scientific Reports},
  author={Carleial, Samuel and Nätt, Daniel and Unternaehrer, Eva and Elbert, Thomas and Robjant, Katy and Wilker, Sarah and Vukojevic, Vanja and Kolassa, Iris-Tatjana and Rukundo-Zeller, Anja C. and Koebach, Anke},
  note={Article Number: 18493}
}

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