Role of Water in CaCO3 Biomineralization

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LU, Hao, Yu-Chieh HUANG, Johannes HUNGER, Denis GEBAUER, Helmut CÖLFEN, Mischa BONN, 2021. Role of Water in CaCO3 Biomineralization. In: Journal of the American Chemical Society. American Chemical Society. 143(4), pp. 1758-1762. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/jacs.0c11976

@article{Lu2021-02-03Water-53227, title={Role of Water in CaCO3 Biomineralization}, year={2021}, doi={10.1021/jacs.0c11976}, number={4}, volume={143}, issn={0002-7863}, journal={Journal of the American Chemical Society}, pages={1758--1762}, author={Lu, Hao and Huang, Yu-Chieh and Hunger, Johannes and Gebauer, Denis and Cölfen, Helmut and Bonn, Mischa} }

2021-03-23T08:21:05Z Biomineralization occurs in aqueous environments. Despite the ubiquity and relevance of CaCO<sub>3</sub> biomineralization, the role of water in the biomineralization process has remained elusive. Here, we demonstrate that water reorganization accompanies CaCO<sub>3</sub> biomineralization for sea urchin spine generation in a model system. Using surface-specific vibrational spectroscopy, we probe the water at the interface of the spine-associated protein during CaCO<sub>3</sub> mineralization. Our results show that, while the protein structure remains unchanged, the structure of interfacial water is perturbed differently in the presence of both Ca<sup>2+</sup> and CO<sub>3</sub><sup>2–</sup> compared to the addition of only Ca<sup>2+</sup>. This difference is attributed to the condensation of prenucleation mineral species. Our findings are consistent with a nonclassical mineralization pathway for sea urchin spine generation and highlight the importance of protein hydration in biomineralization. Bonn, Mischa Cölfen, Helmut 2021-02-03 2021-03-23T08:21:05Z Huang, Yu-Chieh Gebauer, Denis eng Hunger, Johannes Lu, Hao Cölfen, Helmut Role of Water in CaCO<sub>3</sub> Biomineralization terms-of-use Huang, Yu-Chieh Lu, Hao Bonn, Mischa Gebauer, Denis Hunger, Johannes

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