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ERK7 is a negative regulator of protein secretion in response to amino‐acid starvation by modulating Sec16 membrane association

ERK7 is a negative regulator of protein secretion in response to amino‐acid starvation by modulating Sec16 membrane association

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ZACHAROGIANNI, Margarita, Vangelis KONDYLIS, Yang TANG, Hesso FARHAN, Despina XANTHAKIS, Florian FUCHS, Michael BOUTROS, Catherine RABOUILLE, 2011. ERK7 is a negative regulator of protein secretion in response to amino‐acid starvation by modulating Sec16 membrane association. In: The EMBO Journal. EMBO Press. 30(18), pp. 3684-3700. ISSN 0261-4189. eISSN 1460-2075. Available under: doi: 10.1038/emboj.2011.253

@article{Zacharogianni2011-08-16negat-50928, title={ERK7 is a negative regulator of protein secretion in response to amino‐acid starvation by modulating Sec16 membrane association}, year={2011}, doi={10.1038/emboj.2011.253}, number={18}, volume={30}, issn={0261-4189}, journal={The EMBO Journal}, pages={3684--3700}, author={Zacharogianni, Margarita and Kondylis, Vangelis and Tang, Yang and Farhan, Hesso and Xanthakis, Despina and Fuchs, Florian and Boutros, Michael and Rabouille, Catherine} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/50928"> <dc:contributor>Zacharogianni, Margarita</dc:contributor> <dc:contributor>Xanthakis, Despina</dc:contributor> <dc:contributor>Boutros, Michael</dc:contributor> <dcterms:issued>2011-08-16</dcterms:issued> <dc:creator>Kondylis, Vangelis</dc:creator> <dc:contributor>Rabouille, Catherine</dc:contributor> <dc:creator>Fuchs, Florian</dc:creator> <dc:creator>Xanthakis, Despina</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-21T13:18:19Z</dc:date> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-09-21T13:18:19Z</dcterms:available> <dc:contributor>Tang, Yang</dc:contributor> <dc:contributor>Fuchs, Florian</dc:contributor> <dc:creator>Farhan, Hesso</dc:creator> <dc:contributor>Kondylis, Vangelis</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Boutros, Michael</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract xml:lang="eng">RNAi screening for kinases regulating the functional organization of the early secretory pathway in Drosophila S2 cells has identified the atypical Mitotic‐Associated Protein Kinase (MAPK) Extracellularly regulated kinase 7 (ERK7) as a new modulator. We found that ERK7 negatively regulates secretion in response to serum and amino‐acid starvation, in both Drosophila and human cells. Under these conditions, ERK7 turnover through the proteasome is inhibited, and the resulting higher levels of this kinase lead to a modification in a site within the C‐terminus of Sec16, a key ER exit site component. This post‐translational modification elicits the cytoplasmic dispersion of Sec16 and the consequent disassembly of the ER exit sites, which in turn results in protein secretion inhibition. We found that ER exit site disassembly upon starvation is TOR complex 1 (TORC1) independent, showing that under nutrient stress conditions, cell growth is not only inhibited at the transcriptional and translational levels, but also independently at the level of secretion by inhibiting the membrane flow through the early secretory pathway. These results reveal the existence of new signalling circuits participating in the complex regulation of cell growth.</dcterms:abstract> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/50928"/> <dcterms:title>ERK7 is a negative regulator of protein secretion in response to amino‐acid starvation by modulating Sec16 membrane association</dcterms:title> <dc:creator>Zacharogianni, Margarita</dc:creator> <dc:contributor>Farhan, Hesso</dc:contributor> <dc:creator>Tang, Yang</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Rabouille, Catherine</dc:creator> </rdf:Description> </rdf:RDF>

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