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African Nightshade (Solanum scabrum Mill.) : Impact of Cultivation and Plant Processing on Its Health Promoting Potential as Determined in a Human Liver Cell Model

African Nightshade (Solanum scabrum Mill.) : Impact of Cultivation and Plant Processing on Its Health Promoting Potential as Determined in a Human Liver Cell Model

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ODONGO, Grace Akinyi, Nina SCHLOTZ, Susanne BALDERMANN, Susanne NEUGART, Susanne HUYSKENS-KEIL, Benard NGWENE, Bernhard TRIERWEILER, Monika SCHREINER, Evelyn LAMY, 2018. African Nightshade (Solanum scabrum Mill.) : Impact of Cultivation and Plant Processing on Its Health Promoting Potential as Determined in a Human Liver Cell Model. In: Nutrients. 10(10), 1532. eISSN 2072-6643. Available under: doi: 10.3390/nu10101532

@article{Odongo2018-10-17Afric-47840, title={African Nightshade (Solanum scabrum Mill.) : Impact of Cultivation and Plant Processing on Its Health Promoting Potential as Determined in a Human Liver Cell Model}, year={2018}, doi={10.3390/nu10101532}, number={10}, volume={10}, journal={Nutrients}, author={Odongo, Grace Akinyi and Schlotz, Nina and Baldermann, Susanne and Neugart, Susanne and Huyskens-Keil, Susanne and Ngwene, Benard and Trierweiler, Bernhard and Schreiner, Monika and Lamy, Evelyn}, note={Article Number: 1532} }

Lamy, Evelyn 2019-12-05T10:00:09Z Trierweiler, Bernhard Ngwene, Benard Schreiner, Monika terms-of-use Odongo, Grace Akinyi Plant cultivation and processing may impact nutrient and phytochemical content of vegetables. The present study aimed at determining the influence of cultivation and processing on the health promoting capacity of African nightshade (Solanum scabrum Mill.) leaves, an indigenous vegetable, rich in nutrients and phytochemicals. Anti-genotoxicity against the human liver carcinogen aflatoxin B1 (AFB<sub>1</sub>) as determined by the comet assay and radical oxygen species (ROS) scavenging capacity of ethanolic and aqueous extracts were investigated in human derived liver (HepG2) cells. ROS scavenging activity was assessed using electron paramagnetic spin resonance and quantification of ARE/Nrf2 mediated gene expression. The cultivation was done under different environmental conditions. The processing included fermentation and cooking; postharvest ultraviolet irradiation (UV-C) treatment was also investigated. Overall, S. scabrum extracts showed strong health promoting potential, the highest potential was observed with the fermented extract, which showed a 60% reduction of AFB<sub>1</sub> induced DNA damage and a 38% reduction in FeSO<sub>4</sub> induced oxidative stress. The content of total polyphenols, carotenoids and chlorophylls was indeed affected by cultivation and processing. Based on the present in vitro findings consumption of S. scabrum leaves could be further encouraged, preferentially after cooking or fermentation of the plant. eng Trierweiler, Bernhard Baldermann, Susanne Ngwene, Benard Neugart, Susanne 2019-12-05T10:00:09Z African Nightshade (Solanum scabrum Mill.) : Impact of Cultivation and Plant Processing on Its Health Promoting Potential as Determined in a Human Liver Cell Model Huyskens-Keil, Susanne Schlotz, Nina Baldermann, Susanne Neugart, Susanne Schreiner, Monika 2018-10-17 Huyskens-Keil, Susanne Lamy, Evelyn Schlotz, Nina Odongo, Grace Akinyi

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