KOPS - The Institutional Repository of the University of Konstanz

The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum

The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum

Cite This

Files in this item

Checksum: MD5:2aae0a0b576d13824db38716b918ffd7

DOW, Lachlan, Frederike STOCK, Alexandra PELTEKIS, Dávid SZAMOSVÁRI, Michaela PROTHIWA, Adrien LAPOINTE, Thomas BÖTTCHER, Benjamin BAILLEUL, Wim VYVERMAN, Peter G. KROTH, Bernard LEPETIT, 2020. The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum. In: ChemBioChem. Wiley. 21(8), pp. 1206-1216. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201900612

@article{Dow2020-04-17multi-47693, title={The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum}, year={2020}, doi={10.1002/cbic.201900612}, number={8}, volume={21}, issn={1439-4227}, journal={ChemBioChem}, pages={1206--1216}, author={Dow, Lachlan and Stock, Frederike and Peltekis, Alexandra and Szamosvári, Dávid and Prothiwa, Michaela and Lapointe, Adrien and Böttcher, Thomas and Bailleul, Benjamin and Vyverman, Wim and Kroth, Peter G. and Lepetit, Bernard} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/47693"> <dc:contributor>Szamosvári, Dávid</dc:contributor> <dc:creator>Bailleul, Benjamin</dc:creator> <dc:creator>Lapointe, Adrien</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-11-28T10:04:55Z</dc:date> <dc:creator>Stock, Frederike</dc:creator> <dc:creator>Peltekis, Alexandra</dc:creator> <dc:contributor>Stock, Frederike</dc:contributor> <dc:contributor>Peltekis, Alexandra</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:creator>Lepetit, Bernard</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Lapointe, Adrien</dc:contributor> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">The mechanisms underlying interactions between diatoms and bacteria are crucial to understand diatom behaviour and proliferation, and can result in far-reaching ecological consequences. Recently, 2-alkyl-4-quinolones have been isolated from marine bacteria, both of which (the bacterium and isolated chemical) inhibited growth of microalgae, suggesting these compounds could mediate diatom - bacteria interactions. We investigated the effects of several quinolones on three diatom species. The growth of all three was inhibited, with half-maximal inhibitory concentrations reaching the sub-micromolar range. Using multiple techniques, dual inhibition mechanisms were uncovered for 2-heptyl-4-quinolone (HHQ) in Phaeodactylum tricornutum. Firstly, photosynthetic electron transport was obstructed, primarily via inhibition of the cytochrome b6f complex. Secondly, respiration was inhibited, leading to repression of ATP supply to plastids from mitochondria via organelle energy coupling. These data clearly show how HHQ could modulate diatom proliferation in marine environments.</dcterms:abstract> <dcterms:title>The multifaceted inhibitory effects of an alkylquinolone on the diatom Phaeodactylum tricornutum</dcterms:title> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/47693/1/Dow_2-boxfno4ebcrg2.pdf"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Kroth, Peter G.</dc:contributor> <dc:contributor>Lepetit, Bernard</dc:contributor> <dc:contributor>Vyverman, Wim</dc:contributor> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Böttcher, Thomas</dc:creator> <dc:creator>Dow, Lachlan</dc:creator> <dc:contributor>Dow, Lachlan</dc:contributor> <dc:creator>Szamosvári, Dávid</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/47693"/> <dc:creator>Vyverman, Wim</dc:creator> <dcterms:issued>2020-04-17</dcterms:issued> <dc:rights>terms-of-use</dc:rights> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:contributor>Böttcher, Thomas</dc:contributor> <dc:creator>Prothiwa, Michaela</dc:creator> <dc:contributor>Prothiwa, Michaela</dc:contributor> <dc:contributor>Bailleul, Benjamin</dc:contributor> <dc:creator>Kroth, Peter G.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-11-28T10:04:55Z</dcterms:available> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/47693/1/Dow_2-boxfno4ebcrg2.pdf"/> </rdf:Description> </rdf:RDF>

Downloads since Nov 28, 2019 (Information about access statistics)

Dow_2-boxfno4ebcrg2.pdf 19

This item appears in the following Collection(s)

Search KOPS


Browse

My Account