Brain Marker Links Stress and Nicotine Abstinence

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ALLENBY, Cheyenne, Mary FALCONE, Rebecca L. ASHARE, Wen CAO, Leah BERNARDO, E. Paul WILEYTO, Jens PRUESSNER, James LOUGHEAD, Caryn LERMAN, 2020. Brain Marker Links Stress and Nicotine Abstinence. In: Nicotine & tobacco research. Oxford University Press (OUP). 22(6), pp. 885-891. eISSN 1469-994X. Available under: doi: 10.1093/ntr/ntz077

@article{Allenby2020-06Brain-45922, title={Brain Marker Links Stress and Nicotine Abstinence}, year={2020}, doi={10.1093/ntr/ntz077}, number={6}, volume={22}, journal={Nicotine & tobacco research}, pages={885--891}, author={Allenby, Cheyenne and Falcone, Mary and Ashare, Rebecca L. and Cao, Wen and Bernardo, Leah and Wileyto, E. Paul and Pruessner, Jens and Loughead, James and Lerman, Caryn} }

Cao, Wen 2019-05-28T10:39:24Z 2019-05-28T10:39:24Z Bernardo, Leah Background: Subjective stress is a well-documented predictor of early smoking relapse, yet our understanding of stress and tobacco use is limited by reliance on self-reported measures of stress. We utilized a validated functional neuroimaging paradigm to examine whether stress exposure during early abstinence alters objective measures of brain function.<br /><br />Methods: 75 participants underwent blood oxygen level dependent (BOLD) functional magnetic resonance imaging (FMRI) during the Montreal Imaging Stress Task (MIST) on two occasions: once during smoking satiety and once following biochemically confirmed 24-hour abstinence (order counter-balanced). The primary outcome measure was brain response during stress (vs. control) blocks of the MIST, assessed using whole-brain analysis corrected for multiple comparisons using clusters determined by Z≥3.1.<br /><br />Results: Abstinence (vs. satiety) was associated with significantly increased activation in the left inferior frontal gyrus, a brain region associated with inhibitory control. Abstinence-induced change in brain response to stress was positively associated with change in self-reported stress.<br /><br />Conclusions: This study provides objective evidence that the brain response to stress is altered during the first 24 hours of a quit attempt compared to smoking satiety.<br /><br />Implications: These results point to the potential value of inoculating smokers with stress management training prior to a quit attempt. Loughead, James Allenby, Cheyenne Pruessner, Jens Allenby, Cheyenne Ashare, Rebecca L. Brain Marker Links Stress and Nicotine Abstinence Bernardo, Leah Lerman, Caryn terms-of-use Lerman, Caryn Falcone, Mary Loughead, James Falcone, Mary Ashare, Rebecca L. Cao, Wen Wileyto, E. Paul Pruessner, Jens eng Wileyto, E. Paul 2020-06

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