Type of Publication: | Journal article |
Publication status: | Published |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1v71oi5v4dd5w5 |
Author: | Allenby, Cheyenne; Falcone, Mary; Ashare, Rebecca L.; Cao, Wen; Bernardo, Leah; Wileyto, E. Paul; Pruessner, Jens; Loughead, James; Lerman, Caryn |
Year of publication: | 2020 |
Published in: | Nicotine & tobacco research ; 22 (2020), 6. - pp. 885-891. - Oxford University Press (OUP). - eISSN 1469-994X |
Pubmed ID: | 31120113 |
DOI (citable link): | https://dx.doi.org/10.1093/ntr/ntz077 |
Summary: |
Background: Subjective stress is a well-documented predictor of early smoking relapse, yet our understanding of stress and tobacco use is limited by reliance on self-reported measures of stress. We utilized a validated functional neuroimaging paradigm to examine whether stress exposure during early abstinence alters objective measures of brain function.
Methods: 75 participants underwent blood oxygen level dependent (BOLD) functional magnetic resonance imaging (FMRI) during the Montreal Imaging Stress Task (MIST) on two occasions: once during smoking satiety and once following biochemically confirmed 24-hour abstinence (order counter-balanced). The primary outcome measure was brain response during stress (vs. control) blocks of the MIST, assessed using whole-brain analysis corrected for multiple comparisons using clusters determined by Z≥3.1. Results: Abstinence (vs. satiety) was associated with significantly increased activation in the left inferior frontal gyrus, a brain region associated with inhibitory control. Abstinence-induced change in brain response to stress was positively associated with change in self-reported stress. Conclusions: This study provides objective evidence that the brain response to stress is altered during the first 24 hours of a quit attempt compared to smoking satiety. Implications: These results point to the potential value of inoculating smokers with stress management training prior to a quit attempt. |
Subject (DDC): | 150 Psychology |
Keywords: | nicotine, smoking, satiation, brain, stress |
Link to License: | In Copyright |
Bibliography of Konstanz: | Yes |
Refereed: | Yes |
ALLENBY, Cheyenne, Mary FALCONE, Rebecca L. ASHARE, Wen CAO, Leah BERNARDO, E. Paul WILEYTO, Jens PRUESSNER, James LOUGHEAD, Caryn LERMAN, 2020. Brain Marker Links Stress and Nicotine Abstinence. In: Nicotine & tobacco research. Oxford University Press (OUP). 22(6), pp. 885-891. eISSN 1469-994X. Available under: doi: 10.1093/ntr/ntz077
@article{Allenby2020-06Brain-45922, title={Brain Marker Links Stress and Nicotine Abstinence}, year={2020}, doi={10.1093/ntr/ntz077}, number={6}, volume={22}, journal={Nicotine & tobacco research}, pages={885--891}, author={Allenby, Cheyenne and Falcone, Mary and Ashare, Rebecca L. and Cao, Wen and Bernardo, Leah and Wileyto, E. Paul and Pruessner, Jens and Loughead, James and Lerman, Caryn} }
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