Chaperone Interactions at the Ribosome

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

DEUERLING, Elke, Martin GAMERDINGER, Stefan G. KREFT, 2019. Chaperone Interactions at the Ribosome. In: Cold Spring Harbor perspectives in biology. 11(11), a033977. eISSN 1943-0264. Available under: doi: 10.1101/cshperspect.a033977

@article{Deuerling2019-11-01Chape-45845, title={Chaperone Interactions at the Ribosome}, year={2019}, doi={10.1101/cshperspect.a033977}, number={11}, volume={11}, journal={Cold Spring Harbor perspectives in biology}, author={Deuerling, Elke and Gamerdinger, Martin and Kreft, Stefan G.}, note={Article Number: a033977} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:contributor>Deuerling, Elke</dc:contributor> <dcterms:abstract xml:lang="eng">The continuous refreshment of the proteome is critical to maintain protein homeostasis and to adapt cells to changing conditions. Thus, de novo protein biogenesis by ribosomes is vitally important to every cellular system. This process is delicate and error-prone and requires, besides cytosolic chaperones, the guidance by a specialized set of molecular chaperones that bind transiently to the translation machinery and the nascent protein to support early folding events and to regulate cotranslational protein transport. These chaperones include the bacterial trigger factor (TF), the archaeal and eukaryotic nascent polypeptide-associated complex (NAC), and the eukaryotic ribosome-associated complex (RAC). This review focuses on the structures, functions, and substrates of these ribosome-associated chaperones and highlights the most recent findings about their potential mechanisms of action.</dcterms:abstract> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Deuerling, Elke</dc:creator> <dcterms:issued>2019-11-01</dcterms:issued> <dc:creator>Kreft, Stefan G.</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Gamerdinger, Martin</dc:contributor> <dcterms:available rdf:datatype="">2019-05-17T13:37:36Z</dcterms:available> <bibo:uri rdf:resource=""/> <dcterms:title>Chaperone Interactions at the Ribosome</dcterms:title> <dspace:isPartOfCollection rdf:resource=""/> <dc:creator>Gamerdinger, Martin</dc:creator> <dc:date rdf:datatype="">2019-05-17T13:37:36Z</dc:date> <dc:contributor>Kreft, Stefan G.</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


My Account