Features of 3-amino-5-methylisoxazole in heterocyclizations involving pyruvic acids
| Type of Publication: | Journal article |
| Publication status: | Published |
| Author: | Morozova, Alisa D.; Muravyova, Elena A.; Shishkina, Svitlana V.; Sysoiev, Dmytro; Glasnov, Toma; Musatov, Vladimir I.; Desenko, Sergey M.; Chebanov, Valentyn A. |
| Year of publication: | 2019 |
| Published in: | Chemistry of Heterocyclic Compounds ; 55 (2019), 1. - pp. 78-89. - ISSN 0009-3122. - eISSN 1573-8353 |
| DOI (citable link): | https://dx.doi.org/10.1007/s10593-019-02422-8 |
| Summary: |
The chemical properties of 3-amino-5-methylisoxazole in the reactions involving pyruvic acid derivatives are reported. The multicomponent condensation of 3-amino-5-methylisoxazole, aromatic aldehyde, and pyruvic acid was not effective while the treatment of the starting amine with pyruvic acid derivatives led to suitable synthetic procedures for selective synthesis of furanones and pyrrolones. It was established that only NH2-nucleophilic center of 3-amino-5-methylisoxazole takes part in the heterocyclizations with pyruvic acid derivatives.
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| Subject (DDC): | 540 Chemistry |
| Keywords: | 3-amino-5-methylisoxazole, furanones, pyrrolones, pyruvic acids, heterocyclization |
| Refereed: | Yes |
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MOROZOVA, Alisa D., Elena A. MURAVYOVA, Svitlana V. SHISHKINA, Dmytro SYSOIEV, Toma GLASNOV, Vladimir I. MUSATOV, Sergey M. DESENKO, Valentyn A. CHEBANOV, 2019. Features of 3-amino-5-methylisoxazole in heterocyclizations involving pyruvic acids. In: Chemistry of Heterocyclic Compounds. 55(1), pp. 78-89. ISSN 0009-3122. eISSN 1573-8353. Available under: doi: 10.1007/s10593-019-02422-8
@article{Morozova2019-02-18Featu-45603, title={Features of 3-amino-5-methylisoxazole in heterocyclizations involving pyruvic acids}, year={2019}, doi={10.1007/s10593-019-02422-8}, number={1}, volume={55}, issn={0009-3122}, journal={Chemistry of Heterocyclic Compounds}, pages={78--89}, author={Morozova, Alisa D. and Muravyova, Elena A. and Shishkina, Svitlana V. and Sysoiev, Dmytro and Glasnov, Toma and Musatov, Vladimir I. and Desenko, Sergey M. and Chebanov, Valentyn A.} }
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