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Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

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DE FRANCESCO, Davide, Ferdinand W. WIT, Alexander BÜRKLE, Sebastian OEHLKE, Neeltje A. KOOTSTRA, Alan WINSTON, Claudio FRANCESCHI, Paolo GARAGNANI, Chiara PIRAZZINI, Claude LIBERT, 2019. Do people living with HIV experience greater age advancement than their HIV-negative counterparts?. In: AIDS. 33(2), pp. 259-268. ISSN 0269-9370. eISSN 1473-5571. Available under: doi: 10.1097/QAD.0000000000002063

@article{DeFrancesco2019peopl-44505, title={Do people living with HIV experience greater age advancement than their HIV-negative counterparts?}, year={2019}, doi={10.1097/QAD.0000000000002063}, number={2}, volume={33}, issn={0269-9370}, journal={AIDS}, pages={259--268}, author={De Francesco, Davide and Wit, Ferdinand W. and Bürkle, Alexander and Oehlke, Sebastian and Kootstra, Neeltje A. and Winston, Alan and Franceschi, Claudio and Garagnani, Paolo and Pirazzini, Chiara and Libert, Claude} }

Wit, Ferdinand W. Garagnani, Paolo Do people living with HIV experience greater age advancement than their HIV-negative counterparts? Libert, Claude Oehlke, Sebastian De Francesco, Davide Wit, Ferdinand W. Franceschi, Claudio Pirazzini, Chiara Kootstra, Neeltje A. De Francesco, Davide Winston, Alan Bürkle, Alexander Libert, Claude 2019 Kootstra, Neeltje A. Garagnani, Paolo Oehlke, Sebastian Franceschi, Claudio Bürkle, Alexander 2019-01-09T14:47:44Z Winston, Alan 2019-01-09T14:47:44Z terms-of-use eng Objectives: Despite successful antiretroviral (ARV) therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately-chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement.<br /><br />Design: Cross-sectional analysis of 134 PLWH on suppressive ARV therapy, 79 lifestyle-comparable HIV-negative controls aged ≥45 years from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors (BD).<br /><br />Methods: Biological age was estimated using a validated algorithm based on ten biomarkers. Associations between ‘age advancement’ (biological minus chronological age) and HIV status/parameters, lifestyle, cytomegalovirus (CMV), hepatitis B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression.<br /><br />Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2 (11.6, 14.9) years] and HIV-negative [5.5 (3.8, 7.2) years] COBRA participants compared to BD [-7.0 (-4.1, -9.9) years, both p's < 0.001)], but also in HIV-positive compared to HIV-negative participants (p < 0.001). Chronic HBV, higher anti-CMV IgG titer and CD8<sup>+</sup> T-cell count were each associated with increased age advancement, independently of HIV-status/group. Among HIV-positive participants, age advancement was increased by 3.5 (0.1, 6.8) years among those with nadir CD4<sup>+</sup> < 200 cells/μL and by 0.1 (0.06, 0.2) years for each additional month of exposure to saquinavir.<br /><br />Conclusions: Both treated PLWH and lifestyle-comparable HIV-negative individuals show signs of age advancement compared to BD, to which persistent CMV, HBV co-infection and CD8<sup>+</sup> T-cell activation may have contributed. Age advancement remained greatest in PLWH and was related to prior immunodeficiency and cumulative saquinavir exposure. Pirazzini, Chiara

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