Facile Photochemical Modification of Silk Protein–Based Biomaterials

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HARDY, John G., Annabelle BERTIN, Jose Guillermo TORRES-RENDON, Aldo LEAL-EGAÑA, Martin HUMENIK, Felix BAUER, Andreas WALTHER, Helmut CÖLFEN, Helmut SCHLAAD, Thomas R. SCHEIBEL, 2018. Facile Photochemical Modification of Silk Protein–Based Biomaterials. In: Macromolecular Bioscience. 18(11), 1800216. ISSN 1616-5187. eISSN 1616-5195. Available under: doi: 10.1002/mabi.201800216

@article{Hardy2018-11Facil-44082, title={Facile Photochemical Modification of Silk Protein–Based Biomaterials}, year={2018}, doi={10.1002/mabi.201800216}, number={11}, volume={18}, issn={1616-5187}, journal={Macromolecular Bioscience}, author={Hardy, John G. and Bertin, Annabelle and Torres-Rendon, Jose Guillermo and Leal-Egaña, Aldo and Humenik, Martin and Bauer, Felix and Walther, Andreas and Cölfen, Helmut and Schlaad, Helmut and Scheibel, Thomas R.}, note={Article Number: 1800216} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/44082"> <dc:language>eng</dc:language> <dcterms:issued>2018-11</dcterms:issued> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Torres-Rendon, Jose Guillermo</dc:contributor> <dc:creator>Hardy, John G.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-11-29T13:32:45Z</dcterms:available> <dc:creator>Bauer, Felix</dc:creator> <dc:creator>Scheibel, Thomas R.</dc:creator> <dc:creator>Cölfen, Helmut</dc:creator> <dc:creator>Leal-Egaña, Aldo</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Bauer, Felix</dc:contributor> <dc:creator>Torres-Rendon, Jose Guillermo</dc:creator> <dc:contributor>Hardy, John G.</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-11-29T13:32:45Z</dc:date> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/44082"/> <dc:creator>Bertin, Annabelle</dc:creator> <dc:contributor>Bertin, Annabelle</dc:contributor> <dc:contributor>Schlaad, Helmut</dc:contributor> <dc:creator>Humenik, Martin</dc:creator> <dc:contributor>Humenik, Martin</dc:contributor> <dc:contributor>Leal-Egaña, Aldo</dc:contributor> <dcterms:title>Facile Photochemical Modification of Silk Protein–Based Biomaterials</dcterms:title> <dcterms:abstract xml:lang="eng">Silk protein–based materials show promise for application as biomaterials for tissue engineering. The simple and rapid photochemical modification of silk protein–based materials composed of either Bombyx mori silkworm silk or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk‐based materials initiate the polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate potential applications of this type of modification, the polymer‐modified silks are mineralized. The PAA‐ and PMAA‐functionalized silks are mineralized with calcium carbonate, whereas the PAAm‐functionalized silks are mineralized with silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the subject of future investigations.</dcterms:abstract> <dc:contributor>Scheibel, Thomas R.</dc:contributor> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:contributor>Cölfen, Helmut</dc:contributor> <dc:contributor>Walther, Andreas</dc:contributor> <dc:creator>Walther, Andreas</dc:creator> <dc:creator>Schlaad, Helmut</dc:creator> </rdf:Description> </rdf:RDF>

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