KOPS - The Institutional Repository of the University of Konstanz

Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response

Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response

Cite This

Files in this item

Checksum: MD5:7a24c5129b9247fa765b54d8b03a8d6a

MAERTENS, Alexandra, Vy TRAN, Andre KLEENSANG, Thomas HARTUNG, 2018. Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response. In: Frontiers in Genetics. 9, 508. eISSN 1664-8021. Available under: doi: 10.3389/fgene.2018.00508

@article{Maertens2018-11-12Weigh-44079, title={Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response}, year={2018}, doi={10.3389/fgene.2018.00508}, volume={9}, journal={Frontiers in Genetics}, author={Maertens, Alexandra and Tran, Vy and Kleensang, Andre and Hartung, Thomas}, note={Article Number: 508} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/44079"> <dc:contributor>Hartung, Thomas</dc:contributor> <dc:rights>terms-of-use</dc:rights> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/44079"/> <dc:contributor>Tran, Vy</dc:contributor> <dcterms:issued>2018-11-12</dcterms:issued> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-11-29T12:59:34Z</dcterms:available> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response</dcterms:title> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dc:creator>Hartung, Thomas</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/44079/1/Maertens_2-7euakpykm6vk5.pdf"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/44079/1/Maertens_2-7euakpykm6vk5.pdf"/> <dc:contributor>Kleensang, Andre</dc:contributor> <dc:creator>Kleensang, Andre</dc:creator> <dcterms:abstract xml:lang="eng">Despite Bisphenol-A (BPA) being subject to extensive study, a thorough understanding of molecular mechanism remains elusive. Here we show that using weighted gene correlation network analysis (WGCNA), which takes advantage of a graph theoretical approach to understanding correlations amongst genes and grouping genes into modules that typically have co-ordinated biological functions and regulatory mechanisms, that despite some commonality in altered genes, there is minimal overlap between BPA and estrogen in terms of network topology. We confirmed previous findings that ZNF217 and TFAP2C are involved in the estrogen pathway, and are implicated in BPA as well, although for BPA they appear to be active in the absence of canonical estrogen-receptor driven gene expression. Furthermore, our study suggested that PADI4 and RACK7/ZMYNDB8 may be involved in the overlap in gene expression between estradiol and BPA. Lastly, we demonstrated that even at low doses there are unique transcription factors that appear to be driving the biology of BPA, such as SREBF1. Overall, our data is consistent with other reports that BPA leads to subtle gene changes rather than profound aberrations of a conserved estrogen signaling (or other) pathways.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-11-29T12:59:34Z</dc:date> <dc:creator>Tran, Vy</dc:creator> <dc:creator>Maertens, Alexandra</dc:creator> <dc:contributor>Maertens, Alexandra</dc:contributor> </rdf:Description> </rdf:RDF>

Downloads since Nov 29, 2018 (Information about access statistics)

Maertens_2-7euakpykm6vk5.pdf 101

This item appears in the following Collection(s)

Search KOPS


Browse

My Account