The neural dynamics of deficient memory control in heavily traumatized refugees

Victims of war, torture and natural catastrophes are prone to develop posttraumatic stress disorder (PTSD). These individuals experience the recurrent, involuntary intrusion of traumatic memories. What neurocognitive mechanisms are driving this memory disorder? Here we show that PTSD symptoms in heavily traumatized refugees are related to deficits in the effective control of memory retrieval. In a think/no-think task, PTSD patients were unable to forget memories that they had previously tried to suppress when compared to control participants with the same trauma history but without PTSD. Deficits in voluntary forgetting were clinically relevant since they correlated with memory intrusions in everyday life. Magnetoencephalography (MEG) recorded during suppression attempts revealed that PTSD patients were unable to downregulate signatures of sensory long-term memory traces in the gamma frequency band (70-120 Hz). Thus, our data suggest that the inability to suppress unwanted memories through modulation of gamma activity is related to PTSD symptom severity.

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WALDHAUSER, Gerd T., Martin DAHL, Martina RUF-LEUSCHNER, Veronika MÜLLER, Maggie SCHAUER, Nikolai AXMACHER, Thomas ELBERT, Simon HANSLMAYR, 2018. The neural dynamics of deficient memory control in heavily traumatized refugees. In: Scientific reports. 2018, 8, 13132. eISSN 2045-2322. Available under: doi: 10.1038/s41598-018-31400-x

BibTex

@article{Waldhauser2018-09-03neura-43468,
  year={2018},
  doi={10.1038/s41598-018-31400-x},
  title={The neural dynamics of deficient memory control in heavily traumatized refugees},
  volume={8},
  journal={Scientific reports},
  author={Waldhauser, Gerd T. and Dahl, Martin and Ruf-Leuschner, Martina and Müller, Veronika and Schauer, Maggie and Axmacher, Nikolai and Elbert, Thomas and Hanslmayr, Simon},
  note={Article Number: 13132}
}

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