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Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis

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CHOI, Young I., Jonathan S. DUKE-COHAN, Wei CHEN, Baoyu LIU, Jérémie ROSSY, Thibault TABARIN, Lining JU, Jingang GUI, Katharina GAUS, Ellis L. REINHERZ, 2014. Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis. In: Proceedings of the National Academy of Sciences of the United States of America : PNAS. 111(1), pp. 379-384. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.1314209111

@article{Choi2014-01-07Dynam-43328, title={Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis}, year={2014}, doi={10.1073/pnas.1314209111}, number={1}, volume={111}, issn={0027-8424}, journal={Proceedings of the National Academy of Sciences of the United States of America : PNAS}, pages={379--384}, author={Choi, Young I. and Duke-Cohan, Jonathan S. and Chen, Wei and Liu, Baoyu and Rossy, Jérémie and Tabarin, Thibault and Ju, Lining and Gui, Jingang and Gaus, Katharina and Reinherz, Ellis L.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/43328"> <dc:creator>Duke-Cohan, Jonathan S.</dc:creator> <dc:creator>Rossy, Jérémie</dc:creator> <dc:contributor>Gaus, Katharina</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Choi, Young I.</dc:creator> <dc:creator>Gui, Jingang</dc:creator> <dc:contributor>Chen, Wei</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Duke-Cohan, Jonathan S.</dc:contributor> <dc:contributor>Ju, Lining</dc:contributor> <dc:creator>Ju, Lining</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Tabarin, Thibault</dc:creator> <dc:contributor>Gui, Jingang</dc:contributor> <dc:creator>Gaus, Katharina</dc:creator> <dcterms:title>Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis</dcterms:title> <dc:creator>Reinherz, Ellis L.</dc:creator> <dc:contributor>Tabarin, Thibault</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Rossy, Jérémie</dc:contributor> <dc:contributor>Choi, Young I.</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:issued>2014-01-07</dcterms:issued> <dcterms:abstract xml:lang="eng">Plexins and semaphorins comprise a large family of receptor-ligand pairs controlling cell guidance in nervous, immune, and vascular systems. How plexin regulation of neurite outgrowth, lymphoid trafficking, and vascular endothelial cell branching is linked to integrin function, central to most directed movement, remains unclear. Here we show that on developing thymocytes, plexinD1 controls surface topology of nanometer-scaled β1 integrin adhesion domains in cis, whereas its ligation by sema3E in trans regulates individual β1 integrin catch bonds. Loss of plexinD1 expression reduces β1 integrin clustering, thereby diminishing avidity, whereas sema3E ligation shortens individual integrin bond lifetimes under force to reduce stability. Consequently, both decreased expression of plexinD1 during developmental progression and a thymic medulla-emanating sema3E gradient enhance thymocyte movement toward the medulla, thus enforcing the orchestrated lymphoid trafficking required for effective immune repertoire selection. Our results demonstrate plexin-tunable molecular features of integrin adhesion with broad implications for many cellular processes.</dcterms:abstract> <dc:creator>Chen, Wei</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-09-19T13:48:24Z</dcterms:available> <dc:contributor>Liu, Baoyu</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/43328"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-09-19T13:48:24Z</dc:date> <dc:creator>Liu, Baoyu</dc:creator> <dc:contributor>Reinherz, Ellis L.</dc:contributor> </rdf:Description> </rdf:RDF>

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